Association Between Homocysteine And Stroke Severity
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 11
Abstract
Stroke is one of the leading causes of death and disability throughout the world.The incidence of this disease is increasing with the gradual increase in obesity, diabetes mellitus, hyperlipidemia, hypertension and other cardiac problems. Hyperhomocysteinemia has also been proposed as an important risk factor for stroke especially ischemic stroke. This study was aimed to evaluate the homocysteine levels inischemic stroke patients in comparison to apparently healthy controls and to explore the association betweenhomocysteine and stroke severity (assessed by NIHSS scoring). Materials And Methods: Study included 30 patients of ischemic stroke and 20 apparently healthy controls. Plasma homocysteine and serum lipid profile were estimated in all individuals. NIHSS and GCS scoring was done in all patients. Results: The mean value of homocysteine (µmol/L) (47.34±17.35) was significantly higher in cases when compared to controls (7.28±3.65) (p<0.0001). The median of LDL cholesterol was significantly higher in patients when compared to controls. [Median(mg/dl)(range){Patients-94.5(30-166) vs controls 73(24-95) p=0.0068}]. The median of total cholesterol, VLDL and Triglycerides was higher in cases as compared to controls, but the difference was not significant. Homocysteine in patients had shown a significant positive correlation with NIHSS score (r=0.51, p=0.0039)and volume of infarct(r=0.39,p=0.03) and significant negative correlation with GCS (r = - 0.42, p=0.02). Conclusion: Homocysteine correlated well with severity of ischemic stroke.
Authors and Affiliations
Rohitkumar Bonthapally, Rachel Jacob, Kss Sai Baba, K Rukmini Mridula, I Krishna Mohan, Mohammed Noorjahan
Keywords
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- EP ID EP244902
- DOI 10.9790/0853-1611091316
- Views 66
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