Association between Interleukin 10 Serum Level and Non-Alcoholic Fatty Liver Disease
Journal Title: IOSR Journal of Nursing and health Science - Year 2019, Vol 8, Issue 1
Abstract
Background. In Non-Alcoholic Fatty Liver Disease (NAFLD), there is an inflammatory process due to lipotoxicity resulting in macrophage balance imbalance in the liver. Impaired balance of liver macrophages causes IL-10 production is decline, whereas the function of IL-10 is to repair hepatocellular damage. Through this research, we will study the role of cytokines, especially IL-10 as anti-inflammatory cytokines and laboratory abnormalities, especially liver enzymes and lipid profiles in relation to the pathogenesis and development of NAFLD so that it can be a non-invasive parameter to assess NAFLD severity. Aim. To determine association of serum Interleukin 10 level with NAFLD and other marker associate with NAFLD. Methods. Cross-sectional study of 30 consecutive NAFLD patients who came to Adam Malik General Hospital Medan,, from May to July 2018. NAFLD was diagnosed by abdominal ultrasound. Blood glucose, total cholesterol, triglycerides, high- and low-density lipoproteins, parameters of liver function, and IL-10 were measured in each subject. Continuous variables were expressed as mean ± SD or as median (min-max); qualitative variables were presented as proportions. The Student’s t test or Mann Whitney was performed when two groups were compared. Spearman’s correlation results were expressed as coefficients (r) and p values. Differences were considered significant when P< 0.05. All statistical analyses were performed using the SPSS 22. Results. In comparison with control group, patients with NAFLD showed increased fasting blood sugar levels (160 vs. 99 mg / dl), AST levels (27.1 vs. 20.2 U/L), ALT levels (31.5 vs. 19.3 U /L), Total Cholesterol (259 vs. 174 mg / dL), Triglycerides (175 vs. 122 mg / dL), LDL (180 vs. 88 mg /dL) while HDL levels were lower in NAFLD than controls (40 vs. 61 mg /dL). Serum IL-10 levels were lower in the NAFLD group than controls (0.71 vs. 1.45 pg / ml, p <0.001). There is a negative correlation between IL-10 and AST (r = -0.57, p <0.001), ALT (r = -0.52, p = 0.002), Triglycerides (r = -0.62, p <0.001) and LDL (r = -0.66, p <0.001)) and there is a positive correlation between IL-10 levels and HDL (r = 0.48, p = 0.004) Conclusion. There were significant difference between serum IL-10 levels, Fasting blood glucose, ALT, AST, total cholesterol, triglycerides , LDL and HDL in NAFLD patients compared to controls. There were negative correlation between ALT levels, AST, total cholesterol, triglycerides, and LDL with IL-10 levels while HDL levels were positively correlated with IL-10 levels.
Authors and Affiliations
Wanda Maail, GontarAlamsyah Siregar, Ilhamd .
Stress Level and Coping Behaviors of Psychiatric Nursing Students Pre and Post Clinical Practice
Background: In psychiatric clinical settings, nursing students face complex situations and problems that can lead to distress. This study was aimed to assessing stress level and coping behaviors of psychiatric nursing st...
Effect of Pelvic Floor Muscles Exercises Program on Women’s Sexual Self-Efficacy after Delivery
Background: Normal vaginal delivery affects women’s body organs, especially the genital organs; such changes may cause problems in the sexual relationship. Purpose: This study was conducted with the purpose of identifyin...
Azzam reacquisition skill grading scale and its use in cerebral palsied children
Background: The goal of this work was to show the efficacy of gradual hand skills progression training evaluated by Azzam hand skills progression scale in reacquisition of hand dexterity in hemiplegic C.P. children. Meth...
Prevalence, Effect and Management of Cancer Pain at Garissa, Kenya
High prevalence, negative effect and suboptimal cancer pain management has been reported from resource-limited countries such as Kenya. Precisely, trends of cancer cases are on the increase at Garissa County in Kenya, ye...
Effectiveness of Structured Educational Program on Knowledge and Practice among Nurses Regarding Body Fluid Balance Assessment for Critically Ill Patients
Assessment of fluid status and maintaining its' balance is a very important conceptfor critically illpatients. The aim of this study:To evaluate effectiveness of structured educational program on knowledge and practice a...