Association between overweight and obesity in schoolchildren with rs9939609 polymorphism (FTO) and family history for obesity
Journal Title: Jornal de Pediatria - Year 2016, Vol 92, Issue 5
Abstract
Objective To determine the association between overweight/obesity in schoolchildren with FTO rs9939609 polymorphism (fatmass and obesity associated) and family history of obesity. Methods Cross-sectional study comprising a sample of 406 children aged 7–17 years in a city in southern Brazil. Overweight/obesity in schoolchildren was assessed by body mass index (BMI), and family history of obesity was self-reported by parents. Polymorphism genotyping was performed by real time PCR (polymerase chain reaction). The association between the nutritional status of schoolchildren with the presence of family obesity, stratified by polymorphism genotypes (AA [at-risk for obesity], AT, and TT), was assessed by prevalence ratio values (PR) through Poisson regression. Results Among schoolchildren with the AA genotype, 57.4% had overweight/obesity; the percentage was lower for the AT and TT genotypes (33.1% and 28.9%, respectively). Overweight/obesity in schoolchildren was associated with a family history of obesity, especially among children with the AA genotype. The prevalence was higher among those with an obese mother (PR: 1.28; p<0.001), obese maternal or paternal grandmother (PR: 1.22; p=0.047), and obese paternal grandfather (PR: 1.32; p<0.001). Conclusions There is an association between the AA genotype of rs9939609 polymorphism and BMI among schoolchildren. The association between overweight/obesity in schoolchildren with a family history of obesity was found mainly among students with the AA genotype.
Authors and Affiliations
Cézane Priscila Reuter
Keywords
Related Articles
- EP ID EP512149
- DOI 10.1016/j.jped.2015.11.005
- Views 68
- Downloads 0
Chromosomal microarrays testing in children with developmental disabilities and congenital anomalies
Objectives Clinical use of microarray-based techniques for the analysis of many developmental disorders has emerged during the last decade. Thus, chromosomal microarray has been positioned as a first-tier test. This stud...
The formation of citizens: the pediatrician's role
Objective This review article aims to define the fundamental role of the pediatrician in the formation of citizens in the 21st century. Source of data Significant bibliographical contributions produced by neuroscience,...
Autism in 2016: additional discovery
To the Editor, Posar and Visconti1 have recently published their narrative biomedical review on the developments in the field of autism research in 2016, with a particular focus on the hypothetical role of environmental...
Tobacco smoke: it is time for pediatricians to feel directly concerned
It has been stated that the epidemic consequences of smoking-associated diseases rank among the greatest public health catastrophes in the past century.1 Many cancers as well as chronic diseases have tobacco as their spe...
Effects of physical activity on children's growth
Objective To describe the current scientific knowledge on the effects of physical exercise on the growth of children and adolescents since intrauterine life. Source of data A search was carried out in the Medline, Embas...