Association between Plasma Osmolarity and Mortality in Patients Admitted in ICU at IMCHRC, Indore
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 3
Abstract
Abstract: This research aims to explore the association between serum osmolarity and mortality in patients who are admitted in ICU with a specific category of Hyper Glycemia, Uremia & ACS in ICU of Index Medical College, Indore Total patient studied of 200. Both Genders age between 35-65 years. Patients were divided into three groups disease sub groups based on the diagnosis at admission: cardiac, hyperglycemic& uremia, the association between osmolarity & mortality was evaluated. Strengths and limitations of this study the small sample size. Subgroup analysis based on different admission diagnoses was performed to evaluate the osmolarity of mixed intensive care unit. Osmolarity was calculated in the current study which leads to certain bias despite an optimal equation were used. Using the formula 2x sodium + RBS/ 18+ Urea/2.8. Analysis of the 200 patients revealed relationship between osmolarity and mortality & ICU stay in patients with Hyperglycemic, Hyper Urecemia & Coronary Artery Disease. Both Hypo-osmolarity and hyper natraemia, leading to clinically adverse consequences such as increased in risk of mortality & increase no. of days in ICU cardiovascular, hyperglycemic and renal disorders 34 mortality were noted. 56 hypo osmolarity were associated with increased stay up to 72 hours in ICU. The values of serum osmolarity mortality & mortality were more in patients in Hypo & hyper Osmolarity, with the increasing in no. of days in ICU. Acute coronary syndrome 7–9 Despite the consistency of results hypo-osmolarity but hyper osmolarity was significantly showing is associated with associated with mortality except for extreme increased mortality, hyper osmolarity (=340mmoL/L). In all sub groups, vasopress if use was consistently associated with increased mortality. Hypo-osmolarity is associated with increased mortality in patients who are critically ill but Hper osmolarity as compare to Hypo-osmolarity.
Authors and Affiliations
Dr. Bushra Khanam, Dr. Sudhir Mourya, Dr. Veerendra Singh Patel, Dr. Abhay Sharma
Keywords
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