Association Between Soluble CD40 Ligand and Hypercholesterolemia in Children and Adolescents
Journal Title: The Journal of Pediatric Research - Year 2017, Vol 4, Issue 1
Abstract
Aim: Coronary heart disease is one of the most common causes of death around the world. The pathological process of coronary heart disease like atherosclerosis starts in childhood. During this period thrombosis constitutes a high-risk factor. In this study, we investigated the effect of soluble CD40 ligand (sCD40L) and clotting activation on children and adolescents with hypercholesterolemia. Materials and Methods: Plasma levels of sCD40L, P-selectin, 8-hydroxy-2-deoxyguanosine (8-OHdG), and prothrombin fragment 1+2 [(F) 1+2] were determined in thirty-five hypercholesterolemic patients (20 girls and 15 boys; age, median: 13 years) and forty healthy normocholesterolemic subjects (28 girls and 12 boys; age, median: 13 years). Results: No significant differences were observed between the patient group and controls in terms of age, high-density lipoprotein (HDL) cholesterol, 8-OHdG, F1+2 (p>0.05). However, there were significant differences between the two groups with respect to total cholesterol, low-density lipoprotein (LDL) cholesterol, very LDL cholesterol, triglycerides, sCD40L and P-selectin (p<0.05), which were higher in the patient group than the controls. A positive correlation was observed between sCD40L and P-selectin (p<0.05) in accordance with the Spearman correlation analysis. The correlation coefficients were 0.735 in the patient group and 0.647 in the control group. But there was no significant correlation between sCD40L and total cholesterol, LDL-cholesterol, HDL-cholesterol, very LDL-cholesterol, triglycerides, 8-OHdG, F1+2 (p>0.05). Conclusion: We believe that future prospective studies to determine the increase in the level of sCD40L with a larger sample size of a pediatric population with dyslipidemias may be more helpful in predicting the risk of cardiovascular disease.
Authors and Affiliations
Aynur Küçükçongar Yavaş, Tuba Fatma Eminoğlu, İlyas Okur, Arzu Aral, Alev Hasanoğlu, Leyla Tümer
Keywords
Related Articles
- EP ID EP242032
- DOI 10.4274/jpr.24654
- Views 137
- Downloads 0
How Parents of Children with Cancer Seek Information Through Online Communities: A Netnography Study
Aim: This study aims to examine how parents of children with cancer seek information through online communities, using netnography methods from qualitative study types. Materials and Methods: The study was carried out th...
Clinical Presentation and Follow Up of Patients with Mucopolysaccharidosis Type IVA (Morquio A Disease): Single Center Experience
Aim: Mucopolysaccharidosis Type IVA (MPS IVA), Morquio A, is caused by the deficiency in lysosomal enzyme N-acetylgalactosamine-6-sulfate sulfatase. Multisystemic involvements include skeletal systems, pulmonary disease,...
Seizure Self-Efficacy Scale for Children with Epilepsy: Confirmatory and Exploratory Factor Analysis
Aim: In the past few years, the concept of self-efficacy in children with epilepsy has become increasingly important. This study aimed to analyze the psychometric aspects of the Turkish version of the Seizure Self-Effica...
The Quality of Life and Mental Health in Children with Primary Immunodeficiency
Primary immunodeficiency disorders (PIDs) are characterized by recurrent and numerous infections, autoimmune disorders, and malignancies. These diseases are a heterogeneous group that contains many disorders caused by th...
Peer Bullying in the Preadolescent Stage: Frequency and Types of Bullying and the Affecting Factors
Aim: This study was conducted to determine the types, frequencies and the affecting factors of peer bullying among 6th, 7th, and 8th grade students of secondary schools in a city center in Cappadocia. Materials and Metho...