Association between XRCC3 Thr241Met Polymorphism and the Risk of Cancer in Northern Brazil
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 15, Issue 7
Abstract
Aims: Cancer is a genetic disease characterized by an unbalance between cell growth and regulatory factors. The gene XRCC3 encodes a protein that contributes to the integrity of the genome and XRCC3 Thr241Met variants have their capacity of repair altered. Study Design: Our goal was to evaluate XRCC3 241Met polymorphism in a sample of cancer patients in the city of Macapá. Place and Duration of Study: Laboratory of Molecular Biology (Biological Sciences Program of the Federal University of Amapá), Dr. Alberto Lima Clinical Hospital (Hcal) and Institute of Hematology and Hemotherapy of Amapá between June 2009 and July 2010. Methodology: We analyzed 100 DNA samples of patients (50 cases diagnosed with cancer and 50 controls). DNA samples were amplified and analyzed by PCR-RFLP with the enzyme NLaIII. Results: The molecular analysis revealed that 58% of cases and 12% of controls had the Thr/Met genotype, while 82% of controls and 36% of cases had the Thr/Thr genotype. Conclusion: Non-invasive independent predictors for screening esophageal varices may decrease medical as well as financial burden, hence improving the management of cirrhotic patients. These predictors, however, need further work to validate reliability. The frequency of the Thr/Met genotype was higher among cancer patients when compared to the control group. Our findings suggest that XRCC3 241Met polymorphism may be associated with the risk cancer in the study population.
Authors and Affiliations
Suzane da Silva Cabral, Lorrayne Lacerda Lobato, Rafael Espíndola do Nascimento, Olavo Magalhães Picanço Júnior, Artemis Socorro do Nascimento Rodrigues
Keywords
Related Articles
- EP ID EP341330
- DOI 10.9734/BJMMR/2016/24667
- Views 45
- Downloads 0
Assessment of Levels of Oral Hygiene Awareness, Knowledge, Attitude and Practice among the Students of a Government School in Karachi
Aims: The object of this study was to assess the levels of oral hygiene awareness, knowledge, and practice of the children of a Govt. school belonging to low socioeconomic class in Karachi, and to attract more of the hea...
Correlation between Anthropometric Measures, Lipid Profile and Serum Adiponectin and Steatosis in Nondiabetic Nonalcoholic Fatty Liver Disease
Aims: To assess the relation between the grade of steatosis and anthropometric measures, lipid profile and serum adiponectin in non-diabetic patients with nonalcoholic fatty liver. Study Design: Cross sectional study. P...
The Impact of Health Seeking Behaviour, Educational Attainment and Financial Strength on Home Management of Malaria in Rural Communities in Imo State, Nigeria
Aims: The objectives were to determine the impact of health seeking behaviour, educational attainment and financial Strength on home management of malaria in rural communities in Imo State, Nigeria. Study Design: A descr...
Identification of Candidate Biomarkers and Cancer Genes AHNAK2 and EPPK1 in Pancreatic Cancer
Aims: The lack of specific symptoms at early tumor stages, together with a high biological aggressiveness of the tumor contribute to the high mortality rate for pancreatic cancer (PC). Improved screening for earlier diag...
An Overview of Mineral Trioxide Aggregate in Apexification
Aim: The aim of this paper was to present an overview of Mineral Trioxide Aggregate adjacent to apexification, which discover the properties and clinical approach of MTA on apexification in dentistry. Materials and Meth...