Association of Acute Lymphoblastic Leukemia and MDR1 Gene Polymorphism in an Ethnic Iranian Population
Journal Title: Iranian Journal of Blood and Cancer - Year 2009, Vol 1, Issue 2
Abstract
Background: The frequency of the multi-drug resistance 1 (MDR1) gene C3435T polymorphism differs in various ethnical populations such as Asian, African, and Caucasians populations. A silent C3435T polymorphism in exon 26 of MDR1 has been reported to be associated with a decreased expression of P-gp in TT genotypes carriers compared with CC genotypes carriers. Materials and Methods: To evaluate the association between MDR1 gene C3435T polymorphism and acute lymphocyte leukemia (ALL), 126 ALL patients (72 males and 54 females) with a mean age of 11.42 ± 6.55 and 139 healthy controls (79 males and 60 females) with a mean age of 12.15 ± 7.5 who were referred to Dr. Sheykh hospital, Mashhad, Iran, between 2005-2007 were enrolled in our study and their C3435T MDR1 polymorphism was investigated using PCR-RFLP. Results: The mutant homozygous TT and TC genotypes were found to be associated with the incidence of ALL (p<0.05). There was no significant difference for T allele frequency between ALL patients and healthy controls (OR=1.08, 95% CI 0.84-1.66, p=0.33). Conclusion: TT genotypes carriers are at higher risk of developing ALL than carriers of other genotypes.
Authors and Affiliations
Behnoush Miladpour, Amireh Nejat Shokouhi, Abbas Shirdel, Reza Entezari Heravi, Abdollah Banihashem, Habibollah Esmaeili, Azam Khedri, Javad Behravan
Keywords
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