Association of Alpha-1-Antitrypsin with Asthma
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 3
Abstract
Introduction: Asthma is a chronic inflammatory disease of the airways that affects people of all ages. Alpha-1-antitrypsin (or alpha-1-proteinase inhibitor) is the most abundant circulating proteinase inhibitor. Alpha-1-antitrypsin deficiency has a high morbidity and mortality. Alpha-1-antitrypsin deficiency may present with symptoms that are similar to those of asthma. Aim of the present study was to determine the level of alpha- 1-antitrypsin activity in case of asthma patients to assess the possibility of misdiagnosis which leads to increase morbidity. Material and Methods: The present study included the patients diagnosed with asthma in the department of T.B. and Respiratory Diseases in a span of one year. Blood samples of Patients between age group of 31 to 65 years were collected and analyzed for alpha-1-antitrypsin activity for the present study. The method that was adopted in the present study of serum alpha-1-antitrypsin activity was by measuring the inhibition of trypsin by serum. Results: The serum alpha-1-antitrypsin level was found to be 2.37 + 0.13 mg/ml among the control group, which lies in the normal range. The range of serum alpha-1-antitrypsin activity of the control group is 2 to 2.56 mg/ml. The serum alpha-1-antitrypsin level was found to be 2.26 + 0.36 mg/ml among the sixty asthma patients. Amongst them six patients had alpha-1-antitrypsin less than 2 mg/ml. The range of serum alpha-1-antitrypsin activity of the asthmatic patients was 0.94 to 2.67 mg/ml. Conclusion: Early diagnosis by screening of all asthmatic patients as well as family members of confirmed alpha-1- antitrypsin deficiency cases is needed to decrease incidence of morbidity and mortality in affected individuals
Authors and Affiliations
Humera Khan, Khushtar Anwar Salman
Keywords
Related Articles
- EP ID EP430004
- DOI -
- Views 138
- Downloads 0
Neuroimaging in Elderly with New-Onset Unprovoked Seizures - A Pictorial Review
An unprovoked seizure in elderly is a common occurrence. Various causes of seizures in these patients include cerebrovascular accidents, neurodegenerative disorders like Alzheimer's disease, intracranial tumours and post...
Profile of Echocardiographic Changes in COR Pulmonale
Introduction: Cor pulmonale occurs when the right side of the heart is affected in the setting of chronic lung disease. Cor pulmonale can range clinically from mild changes in right ventricular function to frank right he...
Bacteriological Pattern and Antibiotic Resistance in Children with Urinary Tract Infection in Ulin General Hospital Banjarmasin, Indonesia
Introduction: Changes in pathogenic bacterial patterns of urinary tract infection (UTI) in children and their resistance pattern to antibiotics are a serious problem. The presence of a pattern of bacterial features and s...
Prevalence of Various Etiologic Factors Responsible for Epilepsy - A Hospital based Study
Introduction: Seizure is the most common neurological disorder occurring worldwide. Various etiologic agents are responsible for this condition. The chief risk factors include CNS infection, metabolic disorders and cereb...
Early Post – Operative Intraocular Pressure Rise between Phacoemulsification and Phacotrabeculectomy in Primary Open Angle Glaucoma Patients: A Comparison
Introduction: Phacoemulsification with intraocular lens implantation and triple procedure (phacoemulsification with intraocular lens implantation with trabeculectomy) are associated with a significant intraocular pressur...