Association of BER Genes Polymorhism, XRCC3 and XRCC1 with Risk of Gastric Carcinogenesis: A Case Control Study from Eastern India

Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 8

Abstract

The aim of the study was to investigate the association between XRCC3 Thr241Met and XRCC1 Arg194Trp polymorphism and risk of gastric carcinogenesis in eastern Indian population. A total of 508 subjects (168 patients with gastric cancer, 170 with dyspepsia and 170 controls; age and gender matched) were prospectively investigated for this case control study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was performed to distinguish XRCC3Thr241Met and XRCC1 Arg194Trp polymorphism and risk of Gastric Carcinoma (GC). Statistical analysis was done by two-sample t-test for continuous variables and χ2 test for categorical variables. Logistic regression models were used to find the risk factors for Gastric cancer. Subjects were matched for age and gender in all three groups except GC Vs. HC group. XRCC1 Arg194Trp genotypes were comparable among three group XRCC3Thr241Met Trp/Met has protective role and Met/Met mutant allele does not show any risk of gastric cancer

Authors and Affiliations

Kamalika Roy

Keywords

Related Articles

Gliosarcomas: Are They Still Dreadful?

Introduction: Gliosarcomas are highly malignant tumours of the central nervous system, having the worst prognosis. Gliosarcomas have the same epidemiology and natural history like Glioblastoma whereas the incidence is mo...

Recurrent Prosthetic Valve Thrombosis: Fibrinolytic Treatment for Recurrent Left Sided Prosthetic Valve Thrombosis

Background: Prosthetic valve thrombosis is a devastating complication of valve replacement therapy. Many patients experience recurrent prosthetic valve thrombosis which is accompanied by increased morbidity or mortality....

Myopericytoma -A Perivascular Myoid Cell Tumor with Review of Literature

(perivascularmyoid cell)/PEC (perivascular epitheloid cell) tumors, due to their histomorphological overlapping. Their most common site is superficial soft tissues of extremities particularly distal portions of lower lim...

A Study of Serum Calcium Levels during First Week of Life in Normal Term Neonates

Introduction: Transition from foetal to neonatal life is associated with major changes in fluid and electrolyte levels due to homeostatic control. Aims & Objective: This study was planned to study changes of serum Calciu...

Prescription audit and assessment of drug use pattern using World Health Organization prescribing indicators in a tertiary care teaching and referral hospital in Himachal Pradesh, India

Background: The quality of a prescription reveals the attitude of the prescriber towards rational prescribing. Rational use of drugs is an essential element in achieving high quality patient care. This study aims to audi...

Download PDF file
  • EP ID EP209111
  • DOI -
  • Views 96
  • Downloads 0

How To Cite

Kamalika Roy (2015). Association of BER Genes Polymorhism, XRCC3 and XRCC1 with Risk of Gastric Carcinogenesis: A Case Control Study from Eastern India. Journal of Medical Science And clinical Research, 3(8), 6916-6920. https://europub.co.uk/articles/-A-209111