Association of BER Genes Polymorhism, XRCC3 and XRCC1 with Risk of Gastric Carcinogenesis: A Case Control Study from Eastern India
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 8
Abstract
The aim of the study was to investigate the association between XRCC3 Thr241Met and XRCC1 Arg194Trp polymorphism and risk of gastric carcinogenesis in eastern Indian population. A total of 508 subjects (168 patients with gastric cancer, 170 with dyspepsia and 170 controls; age and gender matched) were prospectively investigated for this case control study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was performed to distinguish XRCC3Thr241Met and XRCC1 Arg194Trp polymorphism and risk of Gastric Carcinoma (GC). Statistical analysis was done by two-sample t-test for continuous variables and χ2 test for categorical variables. Logistic regression models were used to find the risk factors for Gastric cancer. Subjects were matched for age and gender in all three groups except GC Vs. HC group. XRCC1 Arg194Trp genotypes were comparable among three group XRCC3Thr241Met Trp/Met has protective role and Met/Met mutant allele does not show any risk of gastric cancer
Authors and Affiliations
Kamalika Roy
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