Association of BER Genes Polymorhism, XRCC3 and XRCC1 with Risk of Gastric Carcinogenesis: A Case Control Study from Eastern India
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 8
Abstract
The aim of the study was to investigate the association between XRCC3 Thr241Met and XRCC1 Arg194Trp polymorphism and risk of gastric carcinogenesis in eastern Indian population. A total of 508 subjects (168 patients with gastric cancer, 170 with dyspepsia and 170 controls; age and gender matched) were prospectively investigated for this case control study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was performed to distinguish XRCC3Thr241Met and XRCC1 Arg194Trp polymorphism and risk of Gastric Carcinoma (GC). Statistical analysis was done by two-sample t-test for continuous variables and χ2 test for categorical variables. Logistic regression models were used to find the risk factors for Gastric cancer. Subjects were matched for age and gender in all three groups except GC Vs. HC group. XRCC1 Arg194Trp genotypes were comparable among three group XRCC3Thr241Met Trp/Met has protective role and Met/Met mutant allele does not show any risk of gastric cancer
Authors and Affiliations
Kamalika Roy
Keywords
Related Articles
- EP ID EP209111
- DOI -
- Views 75
- Downloads 0
Depression in Hypothyroidism and Risk Factors
Background: There are limited studies on depression in medically ill using current diagnostic tools in India. The present study aims to find the prevalence of depression in patients with hypothyroidism and its associatio...
Evaluation of Role of Autologous Platelet Rich Fibrin in Wound Healing and Bone Regeneration after Mandibular Third Molar Surgery: A Prospective Study
Background: Bony cavities filled with PRF showed healing in the half the time as compared to the time required for physiological healing. Thereby the aim of this study is to evaluate the role of autologous platelet rich...
Prevalence of Microalbuminuria in Patients with Thyroid Dysfunction
Background: In India, 42 million people suffer from various kinds of thyroid disorders. Thyroid dysfunction and microalbuminuria are associated with endothelial dysfunction. Thus establishing a relationship between the t...
A Comparative Study of Effects of Three Different Doses of Dexmedetomidine on Extubation
Background and Aim: Dexmedetomidine is a α2 agonist with sedative, sympatholytic and analgesic properties and hence, it can be a very useful drug in anaesthesia to blunt the stress response to extubation, the smooth emer...
Pattern and Visual Outcome in Paediatric Open Globe Injuries- Two Years Prospective Interventional Study in Tertiary Care Centre in Central India
Purpose: To evaluate the pattern and the final visual outcome in paediatric (Up to 12 years) open globe injuries (OGI) in tertiary care centre in central India. Methods: This was prospective interventional study at depar...