Association of C - reactive protein and uric acid with severity of preeclampsia attending to teaching hospital
Journal Title: International Journal of Clinical Obstetrics and Gynaecology - Year 2018, Vol 2, Issue 1
Abstract
Introduction: Preeclampsia (PE) is one of the main causes of maternal and fetal mortality and morbidity. It is a chief source of morbidity and mortality worldwide. PE is associated with an inflammatory state and with oxidative stress, in maternal circulation. Measuring the CRP and uric acid concentration in preeclamptic women could help in understanding the best course of action for the pregnant woman and the foetus, especially if there is an association between CRP levels and severity of preeclampsia. Objective: To determine the levels of C-reactive protein and uric acid levels in preeclampsia pregnant and to determine severity by the association among CRP, uric acid concentration, BMI and blood pressure. Method: This was a case-control study was conducted at Dept. of obstetrics and gynecology, Narayana medical college Hospital, including pregnant women. 25 PE cases and matched normal pregnants in third trimester were enrolled, clinical history and blood was collected to to assess CRP and Uric acid levels. Results: The serum CRP and uric acid levels were found significantly higher in PE cases than normal pregnants. Uric acid and CRP levels were 5.39±1.76 mg% and 8.26±6.9 mg/l respectively in the study group (cases) compared with 3.72±1.29 mg% and 6.22±4.29 mg/l in controls. There was a positive correlation between CRP and mean arterial pressure and also between CRP and uric acid. Conclusion: Serum uric acid and CRP may be feasible to be used as biomarkers for identifying women at risk of preeclampsia. The aetiology of preeclampsia is not well established but having more information about the condition will help in the monitoring and treatment of the pregnant to ensure her and her baby are well.
Authors and Affiliations
K Kameswaramma
Keywords
Related Articles
- EP ID EP501976
- DOI -
- Views 142
- Downloads 0
Comparison of iron status of normoglycaemic pregnant women with gestational diabetes mellitus: An observational study
Objective: To evaluate/examine the influence of elevated serum ferritin and serum iron as a risk factor for Gestational Diabetes Mellitus Study Design: The study was designed as case control study Study Population: Study...
Comparative study of daily Vs intermittent iron supplementation in pregnant women
Background: Pregnancy is a time in which the risk for developing iron deficiency anemia is highest, because iron requirements are substantially greater than average absorbable iron intakes. This aim of this study to eval...
Comparison of N-acetyl cysteine with metformin on clinical profile in anovulatory infertile women with PCOS
Polycystic ovary syndrome (PCOS) is defined as an ovarian dysfunction syndrome which affects the reproductive, endocrine and metabolic functions. Insulin resistance and hyperandrogenism is found to play a key role in the...
Serum ferritin changes on administration of intravenous iron in iron deficiency anemia in pregnancy
The objective of this study was to see the changes in the serum ferritin levels on administration of intravenous iron sucrose in iron deficiency anemia during 14 to 34 weeks of pregnancy. A clinical trial was performed i...
Left ventricular dysfunction in preeclamptic patients
Pregnancy is the physiological change which causes dramatic and reversible changes in a women cardiovascular system and hemodynamic variables which require necessary adaptations in order to develop fetus normally. When t...