Association of Candida and its antifungal susceptibility pattern in patients with pulmonary tuberculosis
Journal Title: IP International Journal of Medical Microbiology and Tropical Diseases - Year 2017, Vol 3, Issue 3
Abstract
Aim: The purpose of this study was to determine the incidence of Candida species and antifungal susceptibility pattern among smear positive pulmonary tuberculosis patients in a coastal tertiary care teaching hospital. Materials and Method: One hundred and twenty one sputum samples were found to be positive for acid fast bacilli by Ziehl-Neelsen stain. All positive sputum samples were taken into consideration and subjected to standard mycological procedures. Results: Out of 121 patients sputum samples positive for acid fast bacilli, Candida co infection was revealed in 41 samples(33.89%). Candida albicans was the most common species isolated and accounted for 60.98% followed by C.tropicalis(21.95%), C.krusei(9.76%) and C.glabrata(7.31%). Out of 539 AFB negative sputum samples, 107(19.85%) samples yielded the growth of Candida. Candida albicans 69 (64.49%) was the most commonest species followed by Candida tropicalis 35(32.71%). Majority of C.albicans and C.tropicalis were showed resistance to azole group. Only 52% of susceptibility exhibited towards fluconazole and clotrimazole by Candida albicans. Susceptibility of C.tropicalis towards fluconazole(55%) and clotrimazole(33%) was also high. All strains of C.krusie and C.glabrata were showed susceptibility to azole group as well as amphotericin B. Few strains of C.albicans(12%) and C.tropical(12%) were shown resistance to amphotericin B. Conclusion: Candida co infection was found in 33.8% of 121 AFB proven pulmonary tubedrculosis patients. Antifungal susceptibility testing revealed resistance to tested azole drugs as well as to amphtericin B. Hence there is a need to perform the Antifungal susceptibility testing before administering antifungals.
Authors and Affiliations
Kavitha Y, Khaja Moinuddin, Anandi V. , Hajaabdul Nazeer
Keywords
Related Articles
- EP ID EP305722
- DOI 10.18231/2455-6807.2017.0029
- Views 105
- Downloads 0
Seroprevalence of Chikungunya virus infection in Ballari and nearby districts of Karnataka
Background and Objective: Chikungunya virus (CHIKV) is an arthropod-borne virus, causes fever and nonspecific clinical manifestations similar to malaria and other bacterial infections, it is not routinely tested at the h...
Antibiogram of klebsiella pneumoniae recovered from blood stream infection at tertiary care hospital, Baroda, Gujarat
Introduction Antimicrobial abuse is a serious risk factor for the emergence of multidrugresistant MDR pathogens Multidrug resistant MDR Klebsiella pneumoniae is an increasing cause of blood stream infections in India and...
RF and Anti-CCP Antibody Tests- A comparative study in the Diagnosis of Rheumatoid Arthritis in a Tertiary Care Hospital
Introduction: Rheumatoid arthritis (RA) is autoimmune disease associated with chronic inflammation of joints causing deformities and functional impairment. Diagnosis primarily depends on clinical manifestations because o...
Can Silver nanoparticles be an answer to combat the drug resistance?
Introduction Wide spread usage and irrational use of antibiotics results in resistance and it is a major problem worldwide Hence there is a need for alternativesObjective of our Study This study was conducted to evaluate...
Anti-biogram of pneumococcal isolates in a tertiary care hospital
Streptococcus pneumoniae are gram positive normal flora of the upper respiratory tract in humans but are also the primary causative bacterial agents of pneumonia and otitis media mostly in children They are also known to...