Association of cardiovascular risk factors with insulin & insulin resistance in type-2 Diabetes Mellitus patients
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2014, Vol 2, Issue 1
Abstract
Cardiovascular diseases are the most common complications of type 2 diabetes patients with presence of dyslipidemia. Dyslipidemia is characterized by increased triglycerides and decreased HDL cholesterol. The ratios calculated from the lipids and lipoproteins may be useful to know the status of the CVD complications in type 2. In the present study, the concentrations of total cholesterol, triglycerides, HDL cholesterol were estimated from fasting serum samples, followed by the calculations of LDL & VLDL cholesterol and lipoprotein ratios including TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, CRF and non HDL cholesterol. Also estimated insulin level, and homeostasis model assessment for insulin resistance (HOMA-IR) was calculated as discriminator of insulin resistance, from fasting glucose and insulin levels, and association of insulin & insulin resistance with cardiovascular risk factors was evaluated. The present study had included 150 type 2 diabetic subjects and 150 age and sex matched healthy controls. Significant increase in the lipid and lipoprotein levels, except HDL cholesterol which were significantly decreased in type 2 diabetics than controls. BMI, Fasting blood glucose, TC, TG, LDL-C, VLDL-C, TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, Non HDL-C and CRF were positively associated with insulin level and HOMA IR, while HDL-C was negatively associated with insulin and insulin resistance. Therefore, the lipoprotein ratios along with the lipid and lipoprotein levels may be used as markers for insulin resistance and for cardiovascular risk. Keywords: type 2 diabetes mellitus, cardiovascular diseases, Lipoproteins, Triglyceride, total Cholesterol, insulin resistance
Authors and Affiliations
Momin AA, Shaheen B, Bankar MP, Bhoite GM, Yadav RD
Keywords
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