Association of cardiovascular risk factors with insulin & insulin resistance in type-2 Diabetes Mellitus patients
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2014, Vol 2, Issue 1
Abstract
Cardiovascular diseases are the most common complications of type 2 diabetes patients with presence of dyslipidemia. Dyslipidemia is characterized by increased triglycerides and decreased HDL cholesterol. The ratios calculated from the lipids and lipoproteins may be useful to know the status of the CVD complications in type 2. In the present study, the concentrations of total cholesterol, triglycerides, HDL cholesterol were estimated from fasting serum samples, followed by the calculations of LDL & VLDL cholesterol and lipoprotein ratios including TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, CRF and non HDL cholesterol. Also estimated insulin level, and homeostasis model assessment for insulin resistance (HOMA-IR) was calculated as discriminator of insulin resistance, from fasting glucose and insulin levels, and association of insulin & insulin resistance with cardiovascular risk factors was evaluated. The present study had included 150 type 2 diabetic subjects and 150 age and sex matched healthy controls. Significant increase in the lipid and lipoprotein levels, except HDL cholesterol which were significantly decreased in type 2 diabetics than controls. BMI, Fasting blood glucose, TC, TG, LDL-C, VLDL-C, TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, Non HDL-C and CRF were positively associated with insulin level and HOMA IR, while HDL-C was negatively associated with insulin and insulin resistance. Therefore, the lipoprotein ratios along with the lipid and lipoprotein levels may be used as markers for insulin resistance and for cardiovascular risk. Keywords: type 2 diabetes mellitus, cardiovascular diseases, Lipoproteins, Triglyceride, total Cholesterol, insulin resistance
Authors and Affiliations
Momin AA, Shaheen B, Bankar MP, Bhoite GM, Yadav RD
Keywords
Related Articles
- EP ID EP374250
- DOI -
- Views 70
- Downloads 0
Endothelial Dysfunction Markers as Predictive of Nephropathy in Pediatric Type 1 Diabetes
Abstract: Recent studies found a correlation between endothelial dysfunction and the development of diabetic nephropathy. Soluble intracellular adhesion molecule-1(sICAM) and nitric oxide metabolites (NOx) are known mark...
The Effects of remineralizing agents on Microhardness of Bleached Enamel with 40% Hydrogen Peroxide-An Invitro Study
Abstract: Teeth whitening have been accepted as one of the most conservative treatment methods of discolored teeth; however, these materials have also some complications for teeth. The aim of this study was to investigat...
A Study of Intestinal Obstruction and Factors Affecting Morbidity and Mortality Ankur Bhatnagar1,Prashant Shrivastava2*, Arjit Singh3, Tanmay Anand4
Abstract: The present study intends to enumerate various etiological factors of intestinal obstruction and to study various factors that affect the morbidity and mortality from intestinal obstruction. 120 patients of int...
Surgery for Elephantiasis of the lower limbs Dieng P. A, Diatta S, Ba P.O, Ba P.S, Gaye M, Diop M. S, Sow N. F, Fall M. L, Ciss A.G, Ndiaye A, Ndiaye M
Untreated acute lymphedema leads to elephantiasis. Anatomical deformities cause disability and psychological issues. Several types of treatment have been used by practicians since the Antiquity. The aim of this study is...
Towards Development of Excellence in Regional Cancer Centers: Indian Scenario
Cancer undoubtedly is becoming an important public health issue. To tackle the problem a large number of cancer centers are needed to be built in the country. National Cancer Control Program established the Regional Canc...