Association of cerebral white matter lesions with systolic and diastolic blood pressure
Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2025, Vol 51, Issue 1
Abstract
[Objective] To investigate the association of cerebral white matter lesions (WMLs) with systolic and diastolic blood pressure. [Methods] Patients admitted to our department from January 2023 to December 2023 were prospectively recruited for this study. The Fazekas method was used to grade the severity of the periventricular WMLs (P-WMLs) and deep WMLs (D-WMLs). Multivariate logistic regression analyses were performed to examine the association of systolic and diastolic blood pressure with WMLs. [Results] A total of 966 eligible participants were enrolled in this study. The mean age was 65.96±11.35 years and 487 participants (50.41%) were male. The results indicated that the more severe the P-WMLs and D-WMLs, the higher the systolic blood pressure was [P-WMLs:0: (134.41±19.86) mmHg, 1: (136.82±20.47) mmHg, 2:(144.52±21.64) mmHg, 3: (147.80±20.7) mmHg; D-WMLs: 0: (137.49±20.58) mmHg, 1:(139.17±21.33) mmHg, 2:(144.39±21.20) mmHg, 3: (147.50±21.73) mmHg], but not diastolic blood pressure. Multivariate logistic regression analysis showed that an elevated systolic level (P-WMLs: OR=1.02, 95%CI: 0.009-0.021; D-WMLs: OR=1.01, 95%CI: 0.005-0.016) was associated with an increased risk of more severe of P-WMLs and deep D-WMLs. No significant association was observed between diastolic blood pressure and WMLs, whether for P-WMLs or D-WMLs. [Conclusion] The more severe P-WMLs and D-WMLs were, the higher the systolic blood pressure was. Elevated systolic blood pressure was an independent risk factors for more severe of P-WMLs and D-WMLs, but not diastolic blood pressure.
Authors and Affiliations
Mengjiao SUN, Yundong ZHANG, Jing. CHEN
Keywords
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- EP ID EP762098
- DOI 10.3969/j.issn.1002-0152.2025.01.002
- Views 21
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