Association of Chemerin rs17173608 and Vaspin rs2236242 Polymorphisms with Type Two Diabetes Mellitus and its Impact on their Corresponding Serum Levels in Egyptian Population
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 15, Issue 3
Abstract
Type 2 diabetes mellitus (T2DM) is a metabolic pro-inflammatory disorder characterized by chronic hyperglycemia and alteration in circulating adipokines. Chemerin and vaspin have recently been identified as novel adipokines with high expression in adipose tissue of obese and T2DM subjects and with potentially insulin-sensitising properties. This study designed to appraise the susceptibility between rs17173608 chemerin and vaspin rs2236242 genes polymorphism and T2DM in obese Egyptian patients and to assess its influence on the serum level of their corresponding adipokines. Study was conducted on 210 T2DM patients and 140 healthy individual control. Serum chemerin and vaspin levels were measured by enzyme linked immunosorbent assay.The genotypes of the polymorphisms were assessed using the tetra amplification refractory mutation system polymerase chain reaction. TG/GG genotype and G allele of rs 17173608 polymorphism in the chemerin gene showed significant higher frequencies in the diabetic group compared with those in control group. Subjects with TA/AA genotypes were at increased risk for T2DM compared to the TT genotype (OR: 3.5, CI = 12.23-5.48; P< 0.0001). TG/GG genotype carriers of chemerin gene showed increased levels of serum chemerin compared to TT genotype, Moreover TA/AA genotypes carriers of vaspin gene revealed higher vaspin levels compared to TT genotype. Chemerin rs17173608 and vaspin rs2236242 polymorphisms are associated with susceptibility of T2DM related with elevated serum chemerin and vaspin levels suggesting that these polymorphisms affect chemerin and vaspin expression
Authors and Affiliations
Amr M Abdelhamid, Mai A. Zaafan
Keywords
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- EP ID EP598536
- DOI 10.26717/BJSTR.2019.15.002694
- Views 161
- Downloads 0
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