Association of Genetic Variants in hOGG1 and APE1 Genes with Breast Cancer Risk in a Rural Population: A Hospital Based Case-Control Study
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2017, Vol 6, Issue 4
Abstract
Background: Breast Cancer (BC) is a major concern of health risk in urban and rural areas of India. Aim and Objectives: This study was aimed to find out the frequency of polymorphisms in DNA repair genes, human 8-oxoguanine DNA glycosylase 1 (hOGG1) at codon (cd) 326 and Apurinic/apyrimidinic endonuclease 1 (APE1) at cd 148 in patients of BC from Maharashtra and to evaluate their association with BC development. Material and Methods: We used Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) to examine gene polymorphisms in 170 patients with BC and 200 in age and sex matched disease-free controls. Results: The results indicated that there was no significant difference in the genotype distribution between BC patients and controls for hOGG1 (p>0.05). The result showed that allele frequencies of APE1 Glu148 (OR=4.78; 95% CI= (2.55-8.95); p= <0.0001) genotype significantly increased the risk of BC. Conclusion: This study indicates that polymorphisms in cd148 of APE1 gene could play a role in modifying genetic susceptibility of individual to breast cancer in Maharashtrian patients.
Authors and Affiliations
Kailas D Datkhile, Suresh J Bhosale, Madhavi N Patil, Pratik P Durgawale, Satish V Kakade
Keywords
Related Articles
- EP ID EP226860
- DOI -
- Views 102
- Downloads 0
Goldenhar Syndrome: Review of Literature and A Case Report
Goldenhar syndrome is a rare congenital anomaly involving the first and second branchial arches. It has been reported with the incidence between 1:3500 and 1:5600, with a male: female ratio of 3:2. The exact etiology is...
Metastatic Renal Cell Carcinoma Masquerading As Benign Cystic Lesion on Cytology
Clear Cell-Renal Cell Carcinoma (CC-RCC), the most common subtype, accounting for 75% of all RCCs, can metastasize to any part of the body. Nodal metastasis is commonly noted in the pulmonary, tracheal and retroperitonea...
Lymphoepithelial Carcinoma of Parotid Gland- A Case Report
Lymphoepithelial carcinoma (LEC) is most commonly seen in the nasopharynx. Very rarely it is found in the salivary gland, preferably in parotid gland followed by submandibular gland where it accounts for 0.4% of all...
A Cross-sectional Assessment of Knowledge of ASHA Workers
Background: The Government of India launched the th National Rural Health Mission on 5 April 2005. A new band of community based functionaries, named as Accredited Social Health Activist (ASHA) was proposed to escort...
Rapunzel Syndrome - Trichobezoar in a 9 Year Old Girl: A Case Report
We here report a case of 9 years old girl presented in casualty with an acute abdomen and small bowel obstruction and on laprotomy a large trichobezoar was revealed extending into small intestine along with intussuce...