Association of Glucose-6-phosphate dehydrogenase deficiency and hyperbilirubinemia in neonates
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 9
Abstract
Background & objective – Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most important disease of hexose monophosphate pathway. It is an X-linked recessive disease, where the deficiency of the enzyme causes a spectrum of clinical manifestations. The aim of this study was to see the occurrence of G6PD deficiency in neonates and its association with hyperbilirubinemia. Materials & Methods – This retrospective study was carried out in a tertiary care centre between January to September 2016. Neonates of both gender with G6PD deficiency and normal G6PD having hyperbilirubinemia (TSB >5mg/dl) were included. Results – Out of 300 neonates with hyperbilirubinemia, 44% were Glucose-6-phosphate dehydrogenase deficient. Male:female (M:F) ratio of G6PD deficient neonates was 1.6:1. Majority of G6PD deficient neonates had TSB>15 mg/dl; whereas G6PD non-deficient had mostly hyperbilirubinemia at TSB levels <15mg/dl (66.1%). Mean Total serum bilirubin (TSB) in G6PD deficient neonates were more as compared to normal G6PD icteric neonates and was statistically significant (P<0.05). Conclusion – In G6PD deficient neonates’ hyperbilirubinemia is very severe type which may be a risk factor for neurological complications like kernicterus. Therefore, implementation of National control program for screening of G6PD deficiency in neonates will reduce the complications and fatal conditions arising due to this inborn blood disorder.
Authors and Affiliations
Rumi Deori, Snehankar Kalita, Swarnali Devi Baruah
Keywords
Related Articles
- EP ID EP381932
- DOI 10.9790/0853-1709033035.
- Views 89
- Downloads 0
Study of Drug Related Problems in Ambulatory Hemodialysis Patients
A prospective, observational study was conducted for a period of six months in a quaternary care hospital in south India to detect and categorize drug related problems in ambulatory haemodialysis patients. Medication rel...
Efficacy of Retrograde Urethrography and Sonourethrography in the characterisation of male urethral strictures - A comparative study.
Urethral strictures are a major cause of voiding difficulty in adult males and a common complaint faced by the Urologists.The male urethra is classically imaged by Retrograde Urethrography in combination with Voiding Cys...
Study of Incidence of Pyogenic Group of Organisms in Nongonococcal Urethritis Patients
Abstract: To study the Incidence of pyogenic group of organisms in nongonococcal urethritis cases with urine culture and sensitivity in 100 cases. The material for this study consisted 100 male patients of NGU. The incid...
Incidence of Polycystic Ovarian Disease in Adolescent: A Prospective Study at Rims Ranchi
Recently there has been an increase in the incidence of adolescent PCOS1. This is more common in urban as compared to those in rural areas. In this context persistence of physiological hyperinsulinemia may be a cause but...
Clinical Study of Meconium Stained Liquor in Labour Induced with Misoprostol and Its Significance on Fetal Outcome
BACKGROUND &OBJECTIVES: induction of labour constitutes initiating effective uterinecontractions which will help in cervical dilatation and delivery of the baby before onset of spontaneous labour. This study evaluates th...