Association of glutathione-S-transferase P1 genotypes with susceptibility to bronchial asthma in children
Journal Title: Archives of Medical Science - Year 2007, Vol 3, Issue 3
Abstract
Introduction: Asthma is characterized by airway inflammation, a critical component of which is oxidative stress. We describe an association study designed to examine whether allelic variation at the glutathione-S-transferase GSTP1 locus influences expression of asthma. Material and methods: Fifty asthmatic children, thirty-five atopic and fifteen nonatopic, with forty healthy controls were enrolled in the study. All participants were subjected to complete blood count, total serum IgE, skin prick testing and peak expiratory flow rate. Polymerase chain reaction-based assays were performed to determine GSTP1 genotypes among asthmatic and healthy control subjects. We explored whether the GSTP1 substitutions influence susceptibility to asthma and its phenotypes. Results: Among the 90 cases, 43 cases (47.8%) had GSTP1 genotype BB, 39 cases (43.3%) had GSTP1 genotype AA, 6 cases (6.7%) had GSTP1 genotype AB, and 2 cases (2.2%) had GSTP1 genotype AD. We found no significant differences in mean values of total serum IgE and skin test positivity among different genotypes. The PEFR% predicted of the BB genotype was significantly higher than that of both AA and AB genotypes (p
Authors and Affiliations
Sherif M. Abdel-Alim, Manal M. El-Masry, Mona Aziz, Soheir O. El-Bassiony, Azza A. Aly
Keywords
Related Articles
- EP ID EP112936
- DOI -
- Views 158
- Downloads 0
The effect of monosodium glutamate on rat thymocyte proliferation and Bcl-2/bax protein expression
Introduction: Monosodium glutamate (MSG) is one of the commonest food additives in modern nutrition. Recent studies showed the modulatory effect of MSG on rat thymocyte apoptosis in vivo and under in vitro conditions. Ho...
Predictor markers of postoperative atrial fibrillation
Weight reduction decreases NT-proBNP levels in obsese coronary patients with chronic diastolic heart failure
Introduction: This study was designed to evaluate the effect of weight reduction on NT-proBNP levels in hypertensive obese patients with chronic diastolic heart failure (DHF). Obesity exerts a negative impact on the card...
The estimation of clinical and home-based tilt training efficacy
Prognosis and long-term observation of a group of patients with acute coronary syndromes without ST-elevation (ACS-NSTEMI)
Introduction: The clinical assessment of patients with unstable angina is based not only on clinical symptoms, but also on concomitant diseases. The aim of this study was to investigate the adverse outcome in patients re...