Association of HbA1c with Kidney Dysfunction in Diabetes Mellitus and Cardiovascular Diseases
Journal Title: People's Journal of Scientific Research. - Year 2016, Vol 9, Issue 2
Abstract
Diabetes mellitus (DM) and cardiovascular diseases (CVD) are some of the known conditions which predispose an individual to develop chronic kidney disease (CKD). Serum Creatinine (SCr) is the most widely used endogenous marker of GFR (Glomerular Filtration Rate), expressed as its serum concentration or renal clearance. Estimated GFR (eGFR) has been devised for more valid estimate of GFR. Association of HbA1c in renal dysfunction in DM and CVD is recently postulated. The study aimed to evaluate the association of HbA1c & eGFR in DM and CVD. Three hundred seventy subjects including 100 healthy controls, 100 diabetic patients, 100 patients with CVD and 70 patients with both DM and CVD were selected. They were analysed for SCr and HbA1c. The eGFR was calculated by four variable Modification of Diet in Renal Disease (MDRD) equation using QxMD nephrology calculator. Variation in SCr levels among the study groups as compared to controls was not statistically significant. Decrease in e-GFR and increase in HbA1c values in study groups as compared to controls was found statistically significant (p<0.01). Statistically significant positive correlation of HbA1c with SCr values and negative correlation of HbA1c with eGFR values is observed in Controls, DM, and DM with CVD, however, it was not statistically significant in CVD patients. Increased HbA1c in monitoring DM raises an attention for complete evaluation of Renal Function Tests. eGFR can be routinely implemented in renal function tests for early diagnosis of preventable renal impairment due to DM or CVD
Authors and Affiliations
Surekha Prabhu, , Yogesh Pawade,, Rekha Dhamnaskar, , Rashmi Karamchandani
Keywords
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