Association of Helicobacter pylori IgG Antibody with Microvascular Complications in Type II Diabetic Patients
Journal Title: Annual Research & Review in Biology - Year 2015, Vol 5, Issue 4
Abstract
Aims: The aim of this study was to investigate the association between HP infection and microvascular complications of type two diabetes mellitus (T2DM). Study Design: Cross-sectional study. Place and Duration of Study: Shahid Beheshti Hospital of Qom, Iran, between March 2012 and March 2013. Methodology: In this cross-sectional study 211 T2DM patients have been examined. Subjects were divided into two groups (HP+ and HP-) based on HP infection (diagnosed with IgG serology), and the association between these groups and microvascular complications of T2DM including nephropathy (based on protein excretion in 24-hour urine collection), retinopathy (based on examination by an ophthalmologist) and neuropathy (diapason and monofilament examination) has been evaluated. Results: Of the 211 subjects studied, 125 (59.24%) were HP+. The mean diabetes duration was not significantly different in both groups. A significant association was found between HP infection and diabetic neuropathy (p=0.04), but there was no correlation between HP infection and diabetic nephropathy and retinopathy (p=0.2 and p=0.43, respectively). Conclusion: Infection with H. pylori increases the risk of diabetic neuropathy and is considered as a possible risk factor diabetic neuropathy.
Authors and Affiliations
Jamshid Vafaeimanesh, Mohammad Bagherzadeh, Vahid Damanpak, Mahmoud Parham
Keywords
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- EP ID EP353486
- DOI 10.9734/ARRB/2015/11148
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