Association of hepatic function and antioxidant micronutrients with Schistosoma haematobium infection in a Nigerian population
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 7
Abstract
Schistosomiasis is associated with liver damage possibly due to production of free radicals, which can be alleviated by antioxidants. The relationship of hepatic function, lipid peroxidation marker and antioxidant micronutrients in S.haematobium infected and non-infected individuals were investigated. 70 subjects positive for urinary schistosomiasis, 50 negative exposed and 30 negative unexposed were studied. Venous blood was collected into heparinized bottles and plasma separated. Antioxidant trace elements,vitamin E, beta-carotene and malondialdehyde (MDA) were assayed by standard laboratory procedures while liver enzymes activity and bilirubin were estimated using kit. All S.haematobium positive subjects were treated with oral administration of praziquantel (40mg/kg), of which 30 subjects were followed up. Plasma selenium, manganese, vitamin E and beta-carotene were significantly increased in unexposed than in positive and negative groups (p<0.05). MDA was slightly increased (p>0.05) in S.haematobium patients compared to uninfected groups. Aspartate and alanine amino transferases (AST,ALT) were significantly increased in the infected group. Alkaline phosphatase (ALP),gamma glutamyltransferase (GGT) were decreased in the infected than other groups (p<0.01). Manganese was negatively correlated with ALP and GGT in the positive group. In the follow-up treated group, there were inverse associations between Zn, Mn and ALT also AST and Mn (p<0.05). Hepatocellular injury but not cholestasis was associated with S.haematobium. Negative correlations exist between antioxidant micronutrients and cholestatic markers (ALP, GGT) in schistosomiasis and also with AST, ALT in follow-up treated subjects suggesting a protective effect of antioxidant micronutrients on hepatic function in S. haematobium.
Authors and Affiliations
Ayelagbe OG. (Ph. D), Adepoju AE. (M. Sc), Omotade NT (M. Sc), Adedokun SA (M. Sc), Akindele, AA (Ph. D), Ojurongbe O (Ph. D)
Keywords
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- EP ID EP377215
- DOI 10.9790/0853-1707031520.
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