Association of HLA-DQ and IFNL4 polymorphisms with susceptibility to hepatitis B virus infection and clearance
Journal Title: Annals of Hepatology - Year 2016, Vol 15, Issue 4
Abstract
Background and aim. Leukocyte antigen DQ (HLA-DQ) and interferon-λ4 (IFNL4) gene polymorphisms were associated withsusceptibility to chronic hepatitis B and C virus infection. This study further confirmed that variants of these genes were associatedwith susceptibility and spontaneous clearance of HBV infection in a Chinese population. Material and methods. A total of 1,069subjects were recruited and divided into three groups i.e. 397 with CLD (HBV-related chronic liver disease), 434 with SC (spontaneous clearance), and 238 HC (healthy controls). HLA-DQrs9275319 and IFNL4rs368234815, rs12971396, rs12979860, andrs8099917SNPs were genotyped using the Sequenom MassARRAY MALDI-TOF system. Results. HLA-DQ rs9275319 showed a significant association with HBV infection (allele model, OR, 0.514; 95% CI, 0.359-0.738, adjusted p = 0.0003) and with natural clearance (allele model, OR, 1.659; 95% CI, 1.197-2.300, adjusted. However, there was no association between IFNL4 polymorphismand HBV susceptibility or natural clearance (all p > 0.05). The multifactor dimensionality reduction (MDR) test with permutationcorrection showed that a three-way interaction between IFNL4 and HLA-DQ SNPs was identified for HBV susceptibility (permutation p = 0.009 for the best factor model) and clearance (permutation p = 0.014 for the best factor model). Conclusions.The data from the current study provided additional evidence for an SNP-SNP interaction between HLA-DQ and IFNL4 in regulationto HBV infection and natural clearance.
Authors and Affiliations
Jia-Hao Fan, Si-Hui Hou, Li Qing-Ling , Jun Hu, Hong Peng, Jin-Jun Guo
Keywords
Related Articles
- EP ID EP78597
- DOI 10.5604/16652681.1202946
- Views 145
- Downloads 0
Heparin-induced thrombocytopenia testing is over-utilized in cirrhosis & correlates with poor clinical outcomes
Introduction. Heparin-induced thrombocytopenia (HIT) is a serious complication seen in hospitalized, medically-ill patients. Evaluation for HIT using a commercially-available ELISA-based test has become increasingly comm...
Liver fibrosis in bile duct-ligated rats correlates with increased hepatic IL-17 and TGF-β2 expression
Background and rationale for the study. IL-17, TGF-β1/2 are cytokines involved in the development of kidney, pulmonaryand liver fibrosis. However, their expression kinetics in the pathogenesis of cholestatic liver fibro...
Herbal hepatotoxicity and WHO global introspection method
Herbal hepatotoxicity is a rare but highly disputed disease because numerous confounding variables may complicate accurate causality assessment. Case evaluation is even more difficult when the WHO global introspection me...
Hepatopulmonary syndrome - Past to present
Hepatopulmonary syndrome (HPS) is the one of the complication of liver cirrhosis with portal hypertension, irrespective of etiology, age and sex. It has also been observed in non cirrhotic portal hypertension and in acut...
Indications for treatment in chronic HCV infection
HCV Infection is a global burden disease and it is related to the development of progressive liver fibrosis, cirrhosis and hepatocellular carcinoma. At least 80% of the persons that have an acute infection evolve to chro...