Association of HLA-DQ and IFNL4 polymorphisms with susceptibility to hepatitis B virus infection and clearance
Journal Title: Annals of Hepatology - Year 2016, Vol 15, Issue 4
Abstract
Background and aim. Leukocyte antigen DQ (HLA-DQ) and interferon-λ4 (IFNL4) gene polymorphisms were associated withsusceptibility to chronic hepatitis B and C virus infection. This study further confirmed that variants of these genes were associatedwith susceptibility and spontaneous clearance of HBV infection in a Chinese population. Material and methods. A total of 1,069subjects were recruited and divided into three groups i.e. 397 with CLD (HBV-related chronic liver disease), 434 with SC (spontaneous clearance), and 238 HC (healthy controls). HLA-DQrs9275319 and IFNL4rs368234815, rs12971396, rs12979860, andrs8099917SNPs were genotyped using the Sequenom MassARRAY MALDI-TOF system. Results. HLA-DQ rs9275319 showed a significant association with HBV infection (allele model, OR, 0.514; 95% CI, 0.359-0.738, adjusted p = 0.0003) and with natural clearance (allele model, OR, 1.659; 95% CI, 1.197-2.300, adjusted. However, there was no association between IFNL4 polymorphismand HBV susceptibility or natural clearance (all p > 0.05). The multifactor dimensionality reduction (MDR) test with permutationcorrection showed that a three-way interaction between IFNL4 and HLA-DQ SNPs was identified for HBV susceptibility (permutation p = 0.009 for the best factor model) and clearance (permutation p = 0.014 for the best factor model). Conclusions.The data from the current study provided additional evidence for an SNP-SNP interaction between HLA-DQ and IFNL4 in regulationto HBV infection and natural clearance.
Authors and Affiliations
Jia-Hao Fan, Si-Hui Hou, Li Qing-Ling , Jun Hu, Hong Peng, Jin-Jun Guo
Keywords
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- EP ID EP78597
- DOI 10.5604/16652681.1202946
- Views 141
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