Association of hyperuricemia and microalbuminuria in acute myocardial infarction in non-diabetic and non-hypertensive patients
Journal Title: International Archives of Integrated Medicine - Year 2017, Vol 4, Issue 10
Abstract
Background: Hyperuricemia and micro albuminuria are known to occur independently in diabetes and hypertension. Of late the cardiovascular implication of Hyperuricemia and microalbuminuria in the non-diabetic, non-hypertensive patients has received focus. Hyperuricemia and microalbuminuria are independent risk indicators of ischemic heart disease, also indicates severity of the disease and has been considered as important prognostic indicator. Objectives: To measure and compare serum uric acid levels and microalbuminuria in either of patient and control groups and to identify the association of hyperuricemia and microalbuminuria in acute myocardial infarction in non-diabetic and non-hypertensive patients in a tertiary hospital. Materials and methods: A prospective study was conducted for a period of 8 months from February 2011-September 2011. We included 32 MI patients (diagnosed based on the clinical history and ECG changes) along with 32 age and sex matched healthy controls. A p-value of <0.05 was considered to be statistically significant. Serum uric acid and micro albuminuria were measured in these patients by colorimetric and immunoturbidimetric methods respectively. Results: The study group consisted of 50 patients, among them 32 participants were selected for our study. Our results showed significant change in serum uric acid levels and microalbuminuria when compared to healthy volunteers. In addition to that we observed positive association between serum uric acid and microalbuminuria; serum uric acid and body mass index in AMI patients. Combination of Killip class and serum uric acid level after acute myocardial infarction was a good predictor of mortality after AMI. Conclusion: These results indicate that assessment of these novel markers should be undertaken so that effective treatment and appropriate life-style changes can be implemented early to prevent morbidity and mortality.
Authors and Affiliations
NL Varun Mai, Mudumala Issac Abhilash, Chandra Shekhar
Keywords
Related Articles
- EP ID EP410661
- DOI -
- Views 96
- Downloads 0
Prevalence of Geriatric Dermatosis – A Study
Background: Geriatric age is generally taken as the age beyond 65 years. Geriatric skin has a high risk of toxicity due to increased surface area to volume, decreased subcutaneous fat, and high ambient temperature and hu...
Carboplatin - based chemotherapy in advanced ovarian cancer
Eight patients of advanced ovarian cancer were treated with monthly cycles of Ifosfamide, Adriamycin and Carboplatin. Debulking surgery was done in 7 cases. None of the patients had complete response. All eight patients...
A study of primary megaureter – Our experience
Amongst the congenital anomalies of the Ureter, Megaureter is one of the commonest, next only to the various types of duplications. Though every dilated and large ureter can be described as Megaureter, Primary obstructiv...
Maternal and perinatal outcome in antenatal women with hypothyroidism
Background: Maternal hypothyroidism is common disorder of thyroid function in pregnancy and has been associated with miscarriage, foetal loss, preeclampsia, preterm labour, placental abruption, foetal distress, etc. Aim...
Review of virus diseases in the nervous system
Viruses are important to the study of molecular and cellular biology as they provide simple systems that can be used to manipulate and investigate the functions of cells. The study and use of viruses have provided valuab...