Association of Hyperuricemia with Acute Coronary Syndrome, Complications and Outcome
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 5
Abstract
The purpose of this study was to demonstrate the relationship between serum uric acid level and major adverse cardiovascular events during admission and 30-day period after admission across the whole spectrum of acute coronary syndrome (ACS).Total 176 patients with new onset ACS were included in the study. Patients with prior history of coronary artery disease, chronic liver or kidney disease, any malignancy and patients on drugs affecting serum uric acid levels were excluded. Routine laboratory investigations, resting 12 lead ECG and ECHO cardiography were done for all patients. Serum uric acid (SUA) was obtained within 24 hours of admission. The patients were divided into two groups: Group I: 41 patients with elevated serum uric acid (>8.2 mg/dl in males and >6.1 mg/dl in females); Group II: 135 patients with normal serum uric acid levels. We monitored the patients in the hospital and followed the patients for 30 days for the occurrence of major adverse cardiovascular events (MACE). The incidence of MACE and mortality were significantly higher in patients with hyperuricemia than in patients with normal serum uric acid during hospital stay and 30 days follow-up (p<0.05). There was a statistically significant correlation between high serum uric acid level and higher Killip class on day of admission. Multivariate logistic regression analysis of data showed a significant difference between group I and II, confirming that SUA can be utilised as a useful biomarker for predicting short-term mortality and MACE in patients with ACS.
Authors and Affiliations
Dr Mahak Garg
Keywords
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