Association of Major Depression with Serum Prolidase Activity and Oxidative Stress
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2017, Vol 20, Issue 4
Abstract
Aim: Stress is a major causative factor for the progression of major depressive disorder (MDD). The present study aimed to know the association of serum prolidase activity (SPA) and oxidative stress with the progression of MDD. Place and Duration of Study: The study was carried out at the Department of Biochemistry, Sir Sunder Lal Hospital, Institute of Medical Sciences (IMS), Banaras Hindu University (BHU), Varanasi, Uttar Pradesh, India. The duration of study was September-2011 to August-2016. Methodology: 80 patients with MDD and 80 healthy controls of matched age and genders were selected. Serums SPA, total oxidant status (TOS), oxidative stress index (OSI) and total antioxidant status (TAS) were measured spectrophotometrically. Results: Increased SPA, TOS, and OSI were observed in patients with MDD than healthy controls (all P < 0.001). However, TAS was significantly decreased (P < 0.001). SPA, TOS and OSI were also increased in patients with > 1 years of MDD than patients with ≤ 1 years of MDD. Positive, linear and significant correlations were observed between duration of MDD and SPA, and TOS, and OSI (all P < 0.001). However, negative, linear and significant correlation was observed between duration of MDD and TAS (P < 0.001). Conclusions: The study concluded that SPA and oxidative stress have been significantly increased in the patients with MDD than healthy individuals. Increased SPA and oxidative stress might be significantly correlated to progression of MDD and may be responsible for its pathogenesis.
Authors and Affiliations
Akhilesh Kumar Verma, Ashutosh Bajpai, Anand Kumar Keshari, Mona Srivastava, Shalabh Srivastava, Ragini Srivastava
Keywords
Related Articles
- EP ID EP311522
- DOI 10.9734/BJMMR/2017/31446
- Views 66
- Downloads 0
Contraceptive Practice of Clients Attending the Family Planning Clinic of the Olabisi Onabanjo University Teaching Hospital, Sagamu, Nigeria
Aim: To examine the socio-demographic characteristics, main source of information about family planning and contraceptive choices of women attending the family planning clinic of a tertiary hospital in Southwest Nigeria....
Prevalence of Allergic Rhinitis Symptoms and Positive Skin Prick Test Results in Children with Recurrent Epistaxis
Background: Allergic Rhinitis is type 1 hypersensitive reaction of nasal mucosa and its primary mediator is IgE. Allergic rhinitis is mostly observed on children and adolescents. To investigate the prevalence of allergic...
Reduced Vascular Endothelial Growth Factor A Levels are Correlated with the Incidence of Brain Edema in Acute Ischemic Stroke Patients
Aims: To study the correlation between the vascular endothelial growth factor A/VEGF-A level and the incidence of brain edema in acute ischemic stroke patients. Study Design: A prospective observational analytic case-co...
The Relationship between TV Viewing and Food Intake and BMI in Preschool Children
Background: Considerable attention is currently being paid to childhood nutrition. Mass media, particularly television (TV), is believed to largely contribute to eating habits and Body mass index (BMI). This study was ca...
Prevalence of Down Syndrome in Western India: A Cytogenetic Study
Aim: To study the prevalence of Down syndrome by conventional chromosome analysis and G-banded karyotyping. Materials and Methods: A retrospective analysis was performed on the case records of2750 paediatrics patients, o...