Association of Maternal Vitamin C Status with Gestational Diabetes Mellitus
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2015, Vol 4, Issue 3
Abstract
Background: The role of antioxidants in the etiology of gestational diabetes mellitus (GDM) has been given limited attention. Vitamin C is a nutrient with radical quenching property and has been claimed to influence glucose tolerance. Aim: To study the association between vitamin C status (dietary intake and plasma concentrations) and GDM. Material and Methods: Using a case-control design with 1:3 ratio we examined 42 pregnant women with GDM and 158 normal glucose tolerant (NGT) gestational age-matched healthy pregnant women at an average of 26 weeks of gestation. Maternal vitamin C intake was determined using detailed semi food frequency questionnaire (SFFQ) and 24 hour diet recall. Plasma vitamin C was determined using a spectrophotometric method in non-fasting samples. GDM was diagnosed by 75 gm oral glucose tolerance test (OGTT) using International Association for Diabetes in Pregnancy Study Group (IADPSG) criteria (fasting ≥92mg%, 1hour ≥180mg%, 2 hour ≥153mg %). Results: GDM women had lower median intake of vitamin C (35.0 mg/day vs. 66.7; p<0.001) and lower median plasma vitamin C concentration (45.9 µmol/L vs. 95.2; p<0.001) compared to NGT women. Plasma vitamin C concentration was inversely related to fasting, 1 hour and 2 hour post glucose plasma glucose concentrations (p<0.001). The associations remained significant after adjustment for age, income, pre-pregnancy BMI, and stress. Conclusion: Our findings suggest that low vitamin C intake as well as low plasma vitamin C concentration is associated with GDM. This association needs to be tested in a large prospective study and subsequently in a clinical trial.
Authors and Affiliations
Hedyeh Masoodi , Trupti Vilas Kamat , Kurus Jhangir Coyaji , Dattatray Shivram Bhat , Kalyanaraman Kumaran , Chitaranjan Sakerlal Yajnik
Keywords
Related Articles
- EP ID EP127460
- DOI -
- Views 82
- Downloads 0
Assessment of Knee Joint Proprioception in Weight Bearing and in Non-Weight Bearing Positions in Normal Subjects
Background: Assessment of proprioception isvaluable for identifying proprioceptive deficits.There are several methods to assess the proprioception.Joint position sense can be assessedin weight bearing (WB) and non weight...
Newborn Care in India: Where do we stand in 2015?
Cytological Diagnosis of Primary Cutaneous Nocardiosis in a Known Case of Lepromatous Leprosy, Syphilis and HIV
Nocardiosis is an acute, subacute or chronic bacterial infection caused by a group of aerobic, gram positive and weakly acid fast species of genus Nocardia. Primary Cutaneous Nocardiosis (PCN) is relatively uncommon...
Opportunities for Cervical Cancer Prevention in India
Morphometric and Histological Analysis of 'SpondylosisDeformans' of Thoracic Region in South-Indian Cadaveric Spines
Background: Osteophyte is a bony outgrowth in the vertebral column. Its high prevalence and clinical importance prompted us to conduct this study of thoracic osteophytes. Aim and Objectives: Morphometric and histological...