Association of plasma hormones, nutritional status, and stressful life events in anorexia nervosa patients
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2014, Vol 68, Issue
Abstract
Objective: The aim of the current study was to analyze the relationships between plasma hormones, body weight parameters and stressful life events in anorexia nervosa (AN).Material and Methods: 72 females in the active phase of AN were evaluated. 52 healthy women constituted the control group. RIA kits were used to measure plasma hormone levels.Results: The concentrations of leptin, insulin, IGF-1, triiodothyronine, LH, FSH, estradiol, and testosterone were significantly lower and those of cortisol and growth hormone significantly higher in the AN than the control group. No hormonal differences between restrictive and binge-purging AN subtypes were found. Leptin, IGF-1, gonadotropins, and sex steroids correlated significantly negatively and growth hormone positively with total reduction of body weight or the degree of undernutrition. Associations were also found between lower insulin concentration and family violence, lower cortisol and psychiatric diseases in the family, higher testosterone and patient’s alcohol or drug abuse.Discussion: The changed activity of the somatotropin-somatomedin, gonadal, and corticotrophin axes corresponds to the clinical stage of AN. Plasma IGF-1 seems to be the most sensitive and useful independent hormonal marker of cachexia.
Authors and Affiliations
Małgorzata Śmiarowska, Krzysztof Safranow, Violetta Dziedziejko, Monika Bialecka, Jerzy Samochowiec
Keywords
Related Articles
- EP ID EP67289
- DOI -
- Views 154
- Downloads 0
Białka z rodziny SMAD: współczesna wiedza na temat ich ekspresji i potencjalnej roli w chorobach nowotworowych
Transformujący czynnik wzrostu beta pełni w ludzkim organizmie wiele istotnych funkcji. Bierze udział m.in. w procesach angiogenezy, reguluje wejście komórek w proces apoptozy oraz wykazuje właściwości stymulujące podzia...
Porównanie użyteczności wybranych wzorów stosowanych do szacowania GFR wśród pacjentów z rozpoznaną przewlekłą chorobą nerek
Streszczenie pracy w angielskiej wersji językowej
Copeptin – stable C-terminal fragment of pre-provasopressin as a new stress marker in newborns
Stress stimuli, including diseases, disturb homeostasis of the body and enhance secretion of various hypothalamus, pituitary and adrenal gland hormones. One of the main hypothalamic hormones secreted in stress conditions...
Moczowa cystatyna C jako biomarker uszkodzenia kanalików nerkowych
Cystatyna C (cysC) jest endogennym inhibitorem peptydaz (proteaz) cysteinowych, który od lat jest obiektem badań jako biomarker funkcji nerek. Ze względu na małe rozmiary i brak białek wiążących cystatyna C jest swobodni...
The roles of orphan nuclear receptors in T-lymphocyte development in the thymus
T-lymphocyte development in the thymus proceeds through successive steps of differentiation, selection and expansion of thymocytes. Multiple signaling proteins and transcription factors play important roles in mediating...