ASSOCIATION OF PLATELET INDICES WITH DISEASE ACTIVITY IN RHEUMATOID ARTHRITIS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 36
Abstract
BACKGROUND Rheumatoid Arthritis (RA) is a chronic autoimmune inflammatory disease of unknown aetiology that mainly affects peripheral joints in a symmetric pattern. Prevalence of RA is approximately 1% worldwide, being two to three times more common in women than men. Effective management in RA requires close monitoring of disease activity. Platelet activation is an important event in synovial inflammation, but very few studies have used platelet indices to assess inflammation. Thus, the aim of the study was to correlate the platelet indices (platelet count, mean platelet volume and platelet distribution width) with disease activity in Rheumatoid Arthritis. MATERIALS AND METHODS This descriptive comparative study was conducted among 60 RA patients and 30 healthy controls within the age group of 30 to 70 years. Every consecutive RA patient who attended the Rheumatology Outpatient Department was included in the study. The severity of RA was assessed by the Disease Activity Score Calculator for Rheumatoid Arthritis (DAS-28). The platelet indices assessed in the study include platelet count, Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW) obtained from their CBC report. The study population was divided into three groups. Group I (Moderate disease activity) with DAS-28 score of 3.2-5.1; Group II (High disease activity) with DAS-28 score above 5.1. Thirty patients in Group I and thirty in Group II were taken for the study. Group III: 30 healthy controls who attended the Master Health Check-Up Department. Data analysis was done by using SPSS software and independent t-test. P value < 0.05 was taken as statistically significant. RESULTS There was statistically significant increase in platelet count, decrease in MPV and PDW in high-grade RA patients when compared with normal individuals (p= 0.004, p= 0.001, p= 0.019 respectively). We also found similar statistical significance between high and moderate grade RA patients (p= 0.001 for platelet count, p= 0.007 for MPV and p= 0.012 for PDW). CONCLUSION Our study suggests that platelet indices can be considered as inflammatory markers for disease activity in RA. However, further studies with larger number of patients are warranted to cross validate our findings.
Authors and Affiliations
Shuba N, Praba V, Prithiviraaj P
Keywords
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- EP ID EP544930
- DOI 10.14260/jemds/2018/881
- Views 63
- Downloads 0
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