Association of Positive Results of Single Serum Biomarker with the Clinical Parameters
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 18, Issue 3
Abstract
Background: Many serum biomarkers have been developed to diagnose cancers at an early stage and monitor drug therapy. At present, the most common clinical used serum-tumor biomarkers are mainly including Alpha-Fetoprotein (AFP), Carcinoembryonic Antigen (CEA), Neurone Specific Enolase (NSE), Total Prostate Specific Antigen (TPSA), Human Epididymis Secretory Protein 4 (HE4), Carbohydrate Antigen 125 (CA125), CA153, CA19-9, CA72-4 and Serum Ferritin (SF). However, more and more studies have shown that serum markers were poor specific and sensitive in cancer early diagnosis, even among the most correlative cancers.Methods: In this work, we screened out and statistically analysed the relationship of the positive results and its distribution for all mentioned above serum biomarkers with the clinical parameters including patient’s gender, age and disease types.Results: We found that most single serum biomarker had relatively low association with cancer, even for the most correlative cancer. we also found that the clinical diagnosis corresponding to single biomarker with high serum levels were various in addition to the diagnosis, treatment and prognosis of the most correlative cancer. Besides, there were no direct relationships of certain serum levels of the biomarkers with the type of disease.Conclusion: In summary, the serum levels of biomarkers cannot be used as the only available criterion for making a clinical decision
Authors and Affiliations
Lin Yu, Yang Luo, Bitao Wu, Bei Xu
Keywords
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- EP ID EP587414
- DOI 10.26717/BJSTR.2019.18.003153
- Views 156
- Downloads 0
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