Association of rs7903146 TCF7L2 (C/T) Gene Polymorphism and Type 2 Diabetes Mellitus in Pakistani Population
Journal Title: Journal of Applied Life Sciences International - Year 2017, Vol 14, Issue 4
Abstract
Among various genetic determinants of type 2 DM (T2DM), TCF7L2 (transcription factor 7 like 2) polymorphisms are among the few verified genetic variants with large effects on the risk of T2DM in different populations. In the current study, the single nucleotide polymorphism (SNP) rs7903146 (c.382-41435C>T) was screened in 322 T2DM cases and 226 controls by genotyping using amplification refractory mutation system-polymerase chain reaction (ARMS-PCR). The TCF7L2 SNP was found to be associated with T2DM; (odd ratio [OR] = 2.72; 95% confidence interval [CI] 2.00-3.71, P = 6.65×10-12). Therefore, we report the role of TCF7L2 variant in individuals with T2DM in Pakistani population.
Authors and Affiliations
Mahmood Hassan Dalhat, Haris Ja’afar Bello, Bashiru Ibrahim, Abdullahi Muhammad Labbo
Keywords
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- EP ID EP318062
- DOI 10.9734/JALSI/2017/37411
- Views 101
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