Association of Serum Phosphorus with Left Ventricular Hypertrophy in Chronic Kidney Disease Patients – A Retrospective Study
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 12
Abstract
Introduction: Chronic Kidney Disease ( CKD) has evolved into a major non communicable disease in India due both to increased incidence and recognition . Higher Phosphorus levels was shown to be associated with adverse cardiovascular outcomes in both patients on maintenance hemodialysis and earlier stages of CKD patients. Community based surveys done in Western Countries showed significant association between serum phosphorus and left ventricular hypertrophy. However, from the available literature there are no Indian studies which focused on this linkage. This retrospective study was an attempt to investigate if such an association exists. Material and Methods: This was a retrospective study conducted on 48 patients diagnosed with Chronic Kidney Disease. We divided them into Predialysis group and hemodialysis group. The study participants were subjected to routine blood investigations including serum phosphorous levels along with 2D ECHO to determine presence of left ventricular hypertrophy , left ventricular mass index. Results: There were 48 patients in the study cohort. 32 of them belonged to Predialysis stage and 16 of them belonged to hemodialysis group . There was a significant positive association between serum phosphorus level and Left ventricular mass in both Predialysis and Hemodialysis patients. Multiple regression analysis showed that BMI, Diastolic Blood Pressure,Serum Phosphorus and Cholesterol levels could predict LV mass to a significant level. Conclusion: In this retrospective cohort study involving Pre dialysis and Dialysis patients, hyperphosphatemia is positively correlated with LV mass.
Authors and Affiliations
Dwarak S, Prasanna Kumar, Raghavendar Reddy Gundepally
Keywords
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