Association of Serum Vascular Endothelial Growth Factor (VEGF) Levels with Nonalcoholic Fatty Liver Disease
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 1
Abstract
Background.Nonalcoholic fatty liver disease (NAFLD) is a growing problem due to the epidemic of obesity. Although the pathogenesis of NAFLD is still not fully understood, some studies suggested that angiogenesismight play a role in its progression. Vascular endothelial growth factor (VEGF) is a main proangiogenic factor implicated in angiogenesis. Aim. To asses the significance of serum VEGF levelsin NAFLD patients. Methods. Cross-sectional study of 40 consecutive NAFLD patients and 40 healthy controls who came to Adam Malik General Hospital Medanbetween May 2018 and July 2018 were included. The NAFLD diagnosis required evidence of hepatic steatosis on ultrasound and exclusion of other causes of liver injury. Serum VEGF levels were determined by an enzyme immunoassayQuantikine Human VEGF-ELISA kit. Univariate analyses, bivariate analyses(T independent test and MannWhitney test) with SPSS version 22. Statistical significant if p< 0,05.Results. From a total of 40 patients, 18 patients (45%) were men with an average age of 44,6 years. Serum VEGF levels were significantly higher in NAFLDpatients compared to healthy controls (315,8pg/mL vs 214,75 pg/mL, p= 0,002). Levels of AST, ALT, fasting blood glucose, total cholesterol, triglyceride, HDL cholesterol and LDL cholesterol were significant difference between NAFLD patients and healthy controls(p<0,001). There were no significant difference of serum VEGF levels in NAFLD patients based on age, sex and Body Mass Index (BMI). Conclusion. Our result showed that serum VEGF levels significant higher in NAFLD patients. This suggest that angiogenesis could play an important role in the pathogenesis of NAFLD.
Authors and Affiliations
Mariati Gurning, GontarAlamsyah Siregar, Masrul Lubis
Keywords
Related Articles
- EP ID EP444191
- DOI 10.9790/0853-1801133640.
- Views 58
- Downloads 0
Matrix Predictor of the Recurrence of Atrial Fibrillation.
Background–Tissue inhibitor of metalloproteinases-1 (TIMP-1)is involved in extracellular matrix remodeling whichis considered to be a marker of regulation of matrix metalloproteinase activity. Methods– An enzyme-linked i...
Management of urinary stone disease in a resource limited tertiary hospital.
Background:Urine stone disease is increasingly becoming a common diagnosis in Sub-Saharan Africa. Different factors have been outlined as the cause. The incidence of associated renal function loss is also on the increase...
History of Oral and Maxillofacial Surgery – A Review
Aim: To review the history of oral and maxillofacial surgery since beginning till date to analyze the progress and development arranged in systematic, chronological, comprehensive and reliable form Objectives : To supply...
Why Do Stemi(St Elevation Myocardial Infarction) Patients Present Late –Study In A Tertiary Care Hospital
We indented to study the prevalence and reasons for late presentation in STEMI in a metropolitan city like Chennai in our centre between May 2016 and April 2017 with a detailed questionnaire. Out of 1278 STEMI patients,...
Safety of Rabies vaccine Human I.P. (Purified Vero Cell Rabies Vaccine) - Abhayrab vaccine, manufactured byHuman Biologicals Institute, when administered in Category IIanimal exposure subjects by Intramuscular or Intradermalroute.
Background: Rabies is an enzootic and epizootic disease of worldwide importance. Globally each year, more than 15 million people require post exposure treatment.Rabies is a vaccine-preventable viral disease. Prevention o...