Association of SH2B3 (rs3184504) polymorphism in essential hypertensive patients in south Indian population
Journal Title: International Journal of Life Science - Year 2018, Vol 6, Issue 1
Abstract
Introduction: Essential hypertension (EH) is considered to be the major risk factor associated with cardiovascular, cerebrovascular and renal diseases. Molecular target identification is the key to the development of drug targets. SNP profiling is a basic method which provides insights into targets associated with disease phenotype. The present study is a case control model used to associate EH with one of the promising cell signalling marker SH2B3 expressed in inflammatory conditions. Results: The subjects recruited for the study were genotyped for rs3184504 polymorphism of SH2B3 gene. Female subjects with CC genotype were 1.4 times more susceptible to EH than male subjects. A significant association was observed for CC genotype on adjusting BMI (p value = 0.030, OR = 1.455, 95% CI = 1.036 – 2.042) in females. Consequently, the C vs T allele comparison in additive model also showed a significant difference (p value = 0.023, OR = 1.455, 95% CI = 1.036 – 2.042). Conclusion: Although, several drugs have been developed for combating EH, the incident rate of the disease seems to rise over the past few decades. This fact clearly describes the ineffectiveness of current drugs to control BP and lack of awareness among individuals about the available treatment modalities. Personalized medicine designed to match the physiological conditions of the patient based on his genotype could safely and effectively control the disease. In this context, the SH2B3 (rs3184504) polymorphism is considered to be a significant marker associated with EH in south Indian population especially in female subjects.
Authors and Affiliations
Jayaseelan Vijayashree Priyadharsini, Muthusamy Karthikeyan, Venkatraman Shridevi, Arumugam Paramasivam, Gopalswamy Jayaraman, Thiagarajan Santhiya Sathiyavedu
Keywords
Related Articles
- EP ID EP542446
- DOI -
- Views 117
- Downloads 0
In silico structural characterization of Monooxygenase and dioxygenase enzymes from Danio rerio
Freshwater fish having both retind and dehydretind showed the capabilities of clearing the provitamin A-Status carotenoids into both forms of Vitamin A, either through central or terminal cleavage. The involvement of mon...
Efficacy study of some antiseptics and disinfectants
Antiseptics and Disinfectants are widely used in hospitals and other health care centers to control the growth of microbes on both living tissues and inanimate objects. Different pathogens responded different antiseptics...
Cultivation, Diversity and Bio-Potential of Salix in the Kashmir Himalaya, India
Represented by about 450 species in the world, genus Salix (Salicaceae) is mainly distributed in the temperate regions of the Northern Hemisphere. Salix has been regarded as a platinum crop worldwide and presently its pr...
Indigenous Medicinal plants used by Tribal communities of district Anuppur, Madhya Pradesh
Present paper deals with 30 ethnobotanical plants have been identified for the treatment of various diseases. Herbarium has been prepared which contains information pertaining to botanical name, local name, plants used,...
Observations on Growth and Productions of Indian Major Carps through composite Fish Culture under different Management practices
Three fish culture ponds (P1, P2 and P3) in Nanded district of M.S. under different management practices were selected for study over a period of two years. In the pond P1, culture of Indian major carps was carried witho...