ASSOCIATION OF TELOMERASE ACTIVITY WITH THE PROGNOSIS OF DIABETES MELLITUS IN SAUDI POPULATION
Journal Title: Journal of Experimental Biology and Agricultural Sciences - Year 2017, Vol 5, Issue 0
Abstract
Telomeres are important for chromosome stability and they are replenished by telomerase enzyme.Impaired telomerase activity has a strong association with ageing and diabetes. Research data haveshown that telomerase activity plays a vital role in pathogenesis of type I and type II diabetes byinfluencing pancreatic cell regeneration. This study was aimed to assess telomerase activity in threediabetic groups (type I, type II and gestational diabetes mellitus (GDM)) and compare it with apopulation with normal blood glucose levels to establish a correlation between reduced telomeraseactivity and prognosis of diabetes in the Saudi population. This study was conducted on 200 Saudidiabetic and non-diabetic participants (20-60 years). Peripheral mononuclear cells (PMNCs) wereextracted from the blood samples and the activity of telomerase in the PMNCs was detected by theTRAP-ELISA assay. Results of study revealed that there was no telomerase activity in control healthygroup, moderate activity in type I, some activity in GDM, and significantly high activity in type IIgroup. This might indicate that telomerase activity has a strong correlation to the prognosis of type IIdiabetes. However, the molecular mechanism still needs to be investigated.
Authors and Affiliations
Taha A. Kumosani, Archana P. Iyer, Ayat B. Al-Ghafari, Mazin A. Zamzami
Keywords
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- EP ID EP428020
- DOI 10.18006/2017.5(3).277.281
- Views 84
- Downloads 0
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