ASSOCIATION OF THYROID-STIMULATING HORMONE AND THYROID HORMONES, T3 AND T4 WITH LIPID PROFILE IN GHANAIAN NORMOTENSIVE PREGNANT WOMEN
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2015, Vol 4, Issue 1
Abstract
Thyroid dysfunction during pregnancy is associated with various adverse perinatal and maternal outcomes. Evidence suggests that thyroid stimulating hormone (TSH) may exert extra-thyroidal effects and modify the profile of blood lipids. Data from Ghana on thyroid hormone status and its association with lipid profile in pregnancy is scant. The aim of this was study to determine the association between maternal blood lipid profile and thyroid hormone status in normotensive pregnant women. Serum levels of thyroid stimulating hormone (TSH), thyroxine (FT4), and free triiodothyronine (FT3) in normotensive pregnant women and aged matched non-pregnant women were assayed. Total cholesterol (TC), triglycerides (TG) and high-density lipoprotein (HDL-c) cholesterol were also analyzed. TSH and FT3 levels were significantly different between the two groups, with pregnant women having lower mean TSH and higher FT3 than control subjects. Mean FT4 was not significantly different between the two groups. There was a significant positive correlation between TSH and BMI. However, the correlation between TSH and TC, TSH and TG, FT3 and TG, as well as TSH and FT3 was insignificant. Our results agree with the general consensus that changes occur in levels of TSH and thyroid hormones during pregnancy, albeit within the normal reference range. However, there is the need for gestational-age dependent reference ranges for FT3 and FT4 in the Ghanaian population to adequately assess thyroidal effects of TSH on lipid profile.
Authors and Affiliations
Nii Ayite Aryee| Department of Medical Biochemistry, School of Biomedical and Allied Health Sciences, College of Health Sciences, Korle-Bu Accra, Ghana., Gborsong Cosmos| Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, Korle-Bu, Accra, Ghana., Emmanuel Ayitey Tagoe| Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, Korle-Bu, Accra, Ghana.
Keywords
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