Association of Transcription Factor 7 Like 2 (TCF7L2) rs12255372 (G/T) Gene Polymorphism and Type 2 Diabetes Mellitus
Journal Title: Journal of Advances in Biology & Biotechnology - Year 2017, Vol 15, Issue 4
Abstract
Aim: The rs12255372 of transcription factor 7 like 2 (TCF7L2) was found to be associated with risk of type 2 diabetes mellitus (T2DM) in different populations worldwide. Therefore in the present study we study the relationship between rs12255372 and T2DM in Pakistani population. Methodology: The study comprised of 333 T2DM subjects and 234 normoglycemic control. Genotyping was done using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: Logistic regression analysis of allotyped data revealed association of rs12255372 with T2DM (odd ratio [OR] =2.30; 95% confidence interval [CI] 1.68-3.16, P=3.14× 10-8), also significant association (OR=3.03; 95% CI 2.07-4.43, P=1.00× 10-9) was observed in the dominant model (DM). Upon stratified analysis we observed T alleles in females (OR=3.60; 95% CI 1.94-7.13, P=6.70× 10-6) to be more associated with the disease compared to males (OR=1.94; 95% CI 1.32-2.87, P=4.56× 10-4). GT genotypes of both genders support their allelotypes. Conclusion: The T allele and GT genotype highlight the possible role of rs12255372 in Pakistani T2DM patients.
Authors and Affiliations
Mahmood Hassan Dalhat, Ibrahim Bashiru, Haris Ja’afar Bello, Yusuf Saidu, Abdullahi Yahya Abbas
Keywords
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- EP ID EP318153
- DOI 10.9734/JABB/2017/37464
- Views 99
- Downloads 0
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