Association of Vitamin D levels and Cognitive function in Postmenopausal women
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2017, Vol 4, Issue 2
Abstract
Background: Vitamin D deficiency(VDD) is a major health concern in India, especially in elderly individuals and is adversely associated with neurocognitive function. Aims and Objectives: 1. To assess the 25hydroxy vitamin D [25(OH)D] levels in postmenopausal women and compare it with premenopausal women. 2. To study the association of 25(OH)D levels with markers of cognitive impairment, that is Mini-Mental State examination(MMSE) and Addenbrooke’s Cognitive Examination – Revised(ACE-R) score in postmenopausal women. Materials and Method: A cross sectional study was conducted on 40 postmenopausal women and 40 premenopausal women as controls. The study subjects were analysed for 25(OH)D levels by ELISA and Cognitive function was assessed by using the MMSE and ACE-R score. Appropriate statistical analysis was done. Results: Serum 25(OH)D levels (22.3±13.58 ng/ml Vs 32.4±12.4 ng/ml) in postmenopausal women were significantly lower (p-value = 0.03) when compared to the premenopausal women. A significant positive correlation was found between the 25(OH)D levels and the markers of cognitive decline (i.e) MMSE (r = 0.40) and ACE-R score (r = 0.61) in postmenopausal women. Even though the vitamin D levels in premenopausal women were higher than postmenopausal women, a significant proportion(60%) had vitamin D inadequacy. Conclusion: A significantly lower 25(OH)D levels, MMSE and ACE-R scores were observed in postmenopausal women when compared to premenopausal women. 25(OH)D levels were significantly associated with markers of cognitive decline. These results suggest a potential role of Vitamin D in cognitive dysfunction in postmenopausal women and can be considered as an early marker for cognitive decline.
Authors and Affiliations
R. Sudha, C. K. Vijayasamundeeswari
Keywords
Related Articles
- EP ID EP296855
- DOI 10.18231/2394-6377.2017.0038
- Views 69
- Downloads 0
Gender specific utility of lipid ratios and its correlation with systemic inflammation in acute myocardial infarction (AMI) patients with type 2 diabetes mellitus – A hospital based study
Objective To evaluate Gender specific alterations in the levels of serum lipid profile parameters Total Cholesterol TC Triglycerides TG Low density lipoprotein Cholesterol LDLC High density lipoprotein Cholesterol HDLC n...
Cerebrospinal Fluid Adenosine Deaminase Activity: A Valid Ancillary Test for Tubercular Meningitis
Background: Tuberculosis affects 1.80 million persons every year with 3.70 lakh annual deaths, ~ 10% of which are of meningeal involvement. Diagnosis of Tubercular meningitis is difficult with often under or over diagnos...
A comparative study of serum magnesium in type 2 diabetes mellitus with and without retinopathy and healthy controls and its correlation with glycemic status
Background: Type 2 diabetes mellitus(DM) is a disease of impaired carbohydrate metabolism. The onset of uncontrolled hyperglycemia causes various microvascular complications such as retinopathy and nephropathy. The prese...
Usefulness of serum gamma glutamyl transferase in assessing severity of preeclampsia
Introduction: Pre-eclampsia is a multisystem disorder, unique to pregnant women after twenty weeks of gestation. In India the incidence of pre-eclampsia is reported to be 8-10% of the pregnancy. It contributes significan...
Study of levels of malondialdehyde, super oxide dismutase and hsCrp in serum of non-obese patients with polycystic ovarian syndrome
Background: Polycystic ovarian syndrome (PCOS) is a heterogenous disorder with diverse clinical features. PCOS patients are known to develop long term complications like cardiovascular disease (CVD), type 2 diabetes mell...