Association of Vitamin D levels and Cognitive function in Postmenopausal women

Journal Title: International Journal of Clinical Biochemistry and Research - Year 2017, Vol 4, Issue 2

Abstract

Background: Vitamin D deficiency(VDD) is a major health concern in India, especially in elderly individuals and is adversely associated with neurocognitive function. Aims and Objectives: 1. To assess the 25hydroxy vitamin D [25(OH)D] levels in postmenopausal women and compare it with premenopausal women. 2. To study the association of 25(OH)D levels with markers of cognitive impairment, that is Mini-Mental State examination(MMSE) and Addenbrooke’s Cognitive Examination – Revised(ACE-R) score in postmenopausal women. Materials and Method: A cross sectional study was conducted on 40 postmenopausal women and 40 premenopausal women as controls. The study subjects were analysed for 25(OH)D levels by ELISA and Cognitive function was assessed by using the MMSE and ACE-R score. Appropriate statistical analysis was done. Results: Serum 25(OH)D levels (22.3±13.58 ng/ml Vs 32.4±12.4 ng/ml) in postmenopausal women were significantly lower (p-value = 0.03) when compared to the premenopausal women. A significant positive correlation was found between the 25(OH)D levels and the markers of cognitive decline (i.e) MMSE (r = 0.40) and ACE-R score (r = 0.61) in postmenopausal women. Even though the vitamin D levels in premenopausal women were higher than postmenopausal women, a significant proportion(60%) had vitamin D inadequacy. Conclusion: A significantly lower 25(OH)D levels, MMSE and ACE-R scores were observed in postmenopausal women when compared to premenopausal women. 25(OH)D levels were significantly associated with markers of cognitive decline. These results suggest a potential role of Vitamin D in cognitive dysfunction in postmenopausal women and can be considered as an early marker for cognitive decline.

Authors and Affiliations

R. Sudha, C. K. Vijayasamundeeswari

Keywords

Related Articles

Prognostic significance of Ischemia Modified Albumin and role of high sensitive Creactive protein levels in acute ischemic stroke patients

Introduction: Acute ischemic stroke (AIS) is one of the leading cause of death worldwide and the main causes of long-term disability. Brain CT shows no abnormality in the early event of AIS and the infarct may not be see...

Study of serum ferritin and HbA1c in type 2 diabetes mellitus

Introduction Diabetes is a metabolic disorder characterized by hyperglycaemia which is associated with rise in the HbA1c Excess iron damages cells of pancreas due to oxidative stress which can contribute to pathogenesis...

Evaluation of performance of Lipid Accumulation Product (LAP), an obesity index as a marker for diagnosing overt type 2 diabetes mellitus over Body Mass Index (BMI)

Objectives of the study: To compare the indices available to measure obesity such as BMI and “lipid accumulation product” (LAP) with respect to risk for development of Type-II Diabetes mellitus. Methodology: The study de...

C-Peptide and insulin levels in patients of metabolic syndrome

Metabolic Syndrome (MetS) is cluster of physical conditions and metabolic abnormalities commonly found in association with increased risk for development of type-2 diabetes mellitus (T2DM), cardiovascular disease (CVD)...

A study to evaluate the vitamin D status in rheumatoid arthritis patients

Introduction: Vitamin D deficiency has been shown to be associated with autoimmune diseases, which is a controversial finding in various previous studies. Moreover there are limited studies done on serum vitamin D and it...

Download PDF file
  • EP ID EP296855
  • DOI 10.18231/2394-6377.2017.0038
  • Views 68
  • Downloads 0

How To Cite

R. Sudha, C. K. Vijayasamundeeswari (2017). Association of Vitamin D levels and Cognitive function in Postmenopausal women. International Journal of Clinical Biochemistry and Research, 4(2), 164-167. https://europub.co.uk/articles/-A-296855