Association study of Glutathione S-Transferase polymorphisms and risk of endometriosis in an Iranian population
Journal Title: International Journal of Reproductive BioMedicine - Year 2016, Vol 14, Issue 4
Abstract
Background: Endometriosis influenced by both genetic and environmental factors. Associations of glutathione S-transferases (GSTs) genes polymorphisms in endometriosis have been investigated by various researchers; however, the results are not consistent. Objective: We examined the associations of GSTM1 and GSTT1 null genotypes and GSTP1 313 A/G polymorphisms with endometriosis in an Iranian population. Materials and Methods: In this case-control study, 151 women with diagnosis of endometriosis and 156 normal healthy women as control group were included. The genotyping was determined using multiplex PCR and PCR- RFLP methods. Results: The GSTM1 null genotype was significantly higher (p=0.027) in the cases (7.3%) than the control group (1.3%). There was no significant difference between the frequency of GSTT1 genotypes between the cases and controls. The GSTP1 313 AG genotype was significantly lower (p=0.048) in the case (33.1%) than the control group (44.4%). Conclusion: Our results showed that GSTM1 and GSTP1 polymorphisms may be associated with susceptibility of endometriosis in Iranian women.
Authors and Affiliations
Mina Hassani, Kioomars Saliminejad, Masood Heidarizadeh, Koorosh Kamali, Toktam Memariani, Hamid Reza Khorram Khorshid
Keywords
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