Atopic march in pediatrics: genotype-associated mechanisms Part 2. Perspective genotype-associated mechanisms and markers of atopic disorders in children
Journal Title: Здоров`я дитини - Year 2017, Vol 12, Issue 5
Abstract
The review deals with the data of studies covering last 10 years held in populations of different countries concerning the association of atopic diseases, which compose the atopic march in children (atopic eczema, allergic rhinitis, allergic rhinoconjunctivitis, bronchial asthma) with genes pathologic mutations (single nucleotid polymorphisms — SNP), which encode the molecules participating in allergic inflammation in the skin and mucosae. The review has been made using the PubMed as a search tool. There is analysis of studies provided on the candidate gens for allergic inflammation — interleukin-1-like-receptor-1, sphyngolipid synthesis regulator, glucorticoid receptor gene, programmed cell death gene 4. There are also provided the candidate markers for the severity of atopic diseases course, particularly, atopic eczema: vitamin D, thymus and activation regulated chemokine, TARC/CCl17 and cutaneous T-cell attracting chemokine, CTAC/CCL27. There has been proposed conducting the studies of provided SNP and allergic inflammation markers on Ukrainian pediatric population for working out the personalized genotype-associated approach for diagnosing and management of atopic diseases in Ukrainian pediatric population.
Authors and Affiliations
V. O. Dytiatkovsky
Keywords
Related Articles
- EP ID EP221471
- DOI 10.22141/2224-0551.12.5.2017.109279
- Views 76
- Downloads 0
Clinical Observation of a Child with Down Syndrome and Glucose and Galactose Malapsorbtion Syndrome
The article deals with a clinical case of primary glucose and galactose malabsorption syndrome in a child with Down syndrome. Difficulty in diagnosis of glucose and galactose malabsorption syndrome in this observation is...
Cough in Children: Current Approaches to the Treatment
Introduction. Cough is one of the most common symptoms in the practice of doctors of various specialties, including pediatricians. Cough treatment should be started with the identification of its cause and correct diagno...
Determination of the Biochemical Activity of N-Acetyltransferase Enzyme, NAT2 Gene Production in Children with Environmental Pathology Following Received Treatment
The study of the biochemical activity of the enzyme N-acetyltransferase, NAT2 gene production in children from ecologically unfavorable regions (EUR) is extremely important to identify predisposition to environmental pat...
Markers of Inflammation (IL-4, IL-6, IL-8, IL-10) in Induced Sputum of Children with Bronchitis
The paper presents the results of investigations of the immune system in children with bronchitis. Factors of poor prognosis and transformation of bronchitis in chronic bronchopulmonary pathology were detected, including...
Modern Views on the Pathogenesis of Bronchial Asthma in Children
The article deals with the modern conception of the etiology, pathogenesis, phenotypes of bronchial asthma in children.