ATP-Binding Cassette (ABC) Transporters and Their Role in Inflammatory Bowel Disease (IBD)
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2018, Vol 5, Issue 1
Abstract
Inflammatory bowel disease (IBD) is a chronic, relapsing, idiopathic inflammation of the gastrointestinal tract characterizing chronic colonic inflammation of GIT. This results from the interaction between the various components of the mucosal immune system and the microenvironment. It is considered as an auto immune disease (AID) involving various factors like immune dysregulation, genetic predisposition, dysbiosis of commensal flora and environmental factors. ATP-binding cassette (ABC) transporters are a large superfamily of membrane proteins with various functions and are also expressed on apical lining of intestine. They utilize the energy from ATP hydrolysis for import and export of from ATP hydrolysis for import and export of substrates. The inflammatory changes associated with IBD pathophysiology are may affect the inner mucosal layer structure and affects these transporters modifying their absorptive and secretory functions and protective role against toxic compounds.This subsequently affects the drug absorption and hence IBD treatment. Beside this transporters also play role in drug resistance and their expression is modulated during inflammatory conditions IBD. Therefore regulating the ABC transporter may be useful in controlling the symptoms or treatment of disease. ABC transporters expressed on epithelial lining of intestine could interact with gut pathogens and microbes and could involve in dysbiosis leading to various gastrointestinal disease such as IBD. The information outlined in this review may help in designing new studies for further exploration of ABC transporters and their role in gastrointestinal diseases. This might be beneficial to develop improved innovative approaches. Keywords: Introduction
Authors and Affiliations
Nirmal Verma, Reena Kumari
Keywords
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- EP ID EP591635
- DOI 10.26717/BJSTR.2018.05.001141
- Views 199
- Downloads 0
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