ATTENUATION OF AMIODARONE-INDUCED LUNG, LIVER AND KIDNEY TOXICITY BY NITRIC OXIDE SYNTHASE INHIBITOR, AMINOGUANIDINE IN RATS
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2019, Vol 6, Issue 6
Abstract
Amiodarone (AM) is one of the most important antiarrhythmic drugs. Despite the use of this drug is widespread, it is associated with unwanted systemic effects. The present study was conducted to investigate whether aminoguanidine (AG), an inhibitor of nitric oxide synthase (iNOS) can protect against amiodarone-induced lung, liver and kidney toxicity in rats. Rats divided into four groups, control group: rats received saline. AG- treated group: rats received AG (100 mg/kg, i.p) daily for 15 days. AM- treated group: rats received saline daily for 5 days, followed by AM (100 mg/kg, i.p) for 10 days. AG+AM- treated group: rats received AG (100 mg/kg i.p.) daily for 5 days before and 10 days concomitant with AM (100 mg/kg, i.p). In this study, AM- treated group showed significant decrease in the body weight and significant increase in organs/body weight ratio compared to the control group. Furthermore, there was significant increase in serum AST, ALT, bilirubin, urea and creatinine levels, with a significant decrease in serum albumin level. Moreover, total leukocyte count and protein levels in BALF were significantly increase. In addition, there was significant increase in TNF-α , NO and MDA levels in lung, liver and kidney tissues and, there were histopathological abnormalities in them. The present study demonstrated that AG has a protective effect against AM induced lung, liver and kidney toxicity via its iNOS inhibition, antioxidant and anti-inflammatory effects.
Authors and Affiliations
Dr. Walaa I. Mohammed
Keywords
Related Articles
- EP ID EP670894
- DOI -
- Views 158
- Downloads 0
CROSSED TESTICULAR ECTOPIA: REPORT OF TWO CASES
Crossed testicular ectopia also called transverse testicular ectopia (TTE) is very rare congenital anomaly in which one testis migrate to the opposite hemiscrotum. Unlike the undescended testis, which occurs in approxima...
ANTI-DIABETIC DRUG COMBINATIONS IN TYPE-II DIABETES MELLITUS AND OUTCOME OF PATIENTS’ COMPLIANCE ON FASTING BLOOD GLUCOSE CONTROL
Background: Patients’ adherences to medication and other treatment plans is cornerstone toward attaining glycaemic control in type II diabetes mellitus (T2DM). Objectives: The study assessed the effects of patient compli...
REVIEW ON IMMUNOMODULATION AND IMMUNOMODULATORY ACTIVITY OF SOME MEDICINAL PLANT
Alteration in the immune system can be achieved by immunomodulatory agents from plant source, The use of phytochemicals has been a supportive practice for our immune system against infections since centuries as these dru...
ECTOPIC PANCREAS IN APPENDIX WITH REVIEW OF LITERATUREECTOPIC PANCREAS IN APPENDIX WITH REVIEW OF LITERATURE
Heterotopic pancreas is a congenital disorder defined as the presence of pancreatic tissue in an abnormal location without any anatomical or vascular continuation with the main body of the pancreas. Most common locations...
DEVELOPMENT OF HENOCH-SCHONLEIN PURPURA NEPHRITIS AND MIGRATORY POLYARTHRITIS IN A PATIENT WITH IG A NEPHROPATHY
Henoch-Schonlein purpura is a type of systemic vasculitis characterized by deposition of IgA on the vascular wall. Skin, joints, kidney, gastrointestinal tract and other organs may be affected. In this paper we present a...