ATTENUATION OF CARDIOVASCULAR RESPONSES TO LARYNGOSCOPY AND INTUBATION BY DILTIAZEM AND LIGNOCAINE: A COMPARATIVE STUDY
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2013, Vol 2, Issue 3
Abstract
The study has been designed to investigate the attenuation of cardiovascular responses to laryngoscopy and intubation by diltiazem and lignocaine. Endotracheal intubation is often associated with a hypertension and tachycardia. This response is primarily because of sympatho-adrenal stimulation, associated with laryngoscopy and endotracheal intubation. The rise in the heart rate (HR) and blood pressure increases the myocardial oxygen demand. This increase is tolerated well by normal healthy individuals. However, in patients with Ischemic heart disease (IHD), Hypertensive heart disease and cerebrovascular disease, this sudden rise of heart rate and blood pressure can produce deleterious effects, in the form of myocardial ischemia, pulmonary oedema and cerebral haemorrhage. Many methods, like beta-blockers, deep inhalational anaesthesia, intravenous lignocaine, calcium channel blockers and direct acting vasodilators, have been tried to blunt these harmful pressor responses associated with laryngoscopy and endotracheal intubation. Intravenous lignocaine is a popular method of blunting this response, because of its ability to depress the myocardium and membrane stabilization effect. Diltiazem, a calcium channel blocker can blunt these responses because of its direct acting vasodilating properties and negative chronotropic effect. In view of it, the present study was undertaken to compare the effects of 1.5 mg/kg lignocaine IV given 3 minutes before laryngoscopy and intubation, Diltiazem 0.2 mg/kg IV given 60 seconds before laryngoscopy and intubation and combination of 0.2 mg/kg of diltiazem IV and 1.5 mg/kg of lignocaine IV given 60 seconds before laryngoscope and intubation on laryngoscopic reactions. It was noted that,both lignocaine and diltiazem attenuated the pressor response to laryngoscopy and endotracheal intubation compared to control group. However, the combination of lignocaine and diltiazem gave better protection against the laryngoscopic reaction than when either of the drugs was given alone.
Authors and Affiliations
Mohan K| Department of Anaesthesia, Department of Pharmacology, Sri Sathya Sai Medical College & Research Institute, Tiruporur, Guduvancherry, Ammapettai, Sembakkam, Tamilnadu, India, Corresponding author email: koyeedoctor@gmail.com, Mohana Rupa L| Department of Pharmacology, Sri Sathya Sai Medical College & Research Institute, Tiruporur, Guduvancherry, Ammapettai, Sembakkam, Tamilnadu, India
Keywords
Related Articles
- EP ID EP11017
- DOI 10.5958/j.2319-5886.2.3.098
- Views 390
- Downloads 21
The Role of Early Maladaptive Schemas in Prediction of Dysfunctional Attitudes toward Drug Abuse among Students of university
Drug addiction as the most serious social issue of the world has different sociological, psychological, legal, and political aspects. In this regard, the purpose of this study is to determine the role of early maladapti...
Changing spectrum of renal disease in HIV
The study was done to evaluate the spectrum of various renal histopathological lesions in patients infected with HIV (Human Immunodeficiency Virus).32 HIV positive patients underwent Renal biopsy over a period of 3 year...
Investigating the Effect of Peer Education on Self-Efficacy in Patients with Heart Failure in Selected Hospitals of Saveh County
The present study is a quasi-experimental study in which the effect of peer education on self-efficacy in patients with heart failure was investigated in 2016. The research environment of this study included Shahid Cham...
SILENT UTERINE RUPTURE OF UNSCARRED UTERUS- AN UNUSUAL PRESENTATION
It is very rare to see rupture of uterus in an unscarred uterus. But in cases of previous abortions or cesarean section or scarred uterus, uterine rupture is seen in few cases. Silent uterine rupture is very rare. If th...
PATTERN OF EXTRA-PULMONARY TUBERCULOSIS IN PATIENTS WITH HUMAN IMMUNODEFICIENCY VIRUS INFECTION, AT A TERTIARY CARE CENTRE IN EASTERN INDIA
Introduction: Tuberculosis and Human Immunodeficiency Virus (HIV) co infection is becoming one of the most important public health issues in India. In some developing countries, 40% of all tuberculosis cases are attribu...