ATTENUATION OF CARDIOVASCULAR RESPONSES TO LARYNGOSCOPY AND INTUBATION BY DILTIAZEM AND LIGNOCAINE: A COMPARATIVE STUDY
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2013, Vol 2, Issue 3
Abstract
The study has been designed to investigate the attenuation of cardiovascular responses to laryngoscopy and intubation by diltiazem and lignocaine. Endotracheal intubation is often associated with a hypertension and tachycardia. This response is primarily because of sympatho-adrenal stimulation, associated with laryngoscopy and endotracheal intubation. The rise in the heart rate (HR) and blood pressure increases the myocardial oxygen demand. This increase is tolerated well by normal healthy individuals. However, in patients with Ischemic heart disease (IHD), Hypertensive heart disease and cerebrovascular disease, this sudden rise of heart rate and blood pressure can produce deleterious effects, in the form of myocardial ischemia, pulmonary oedema and cerebral haemorrhage. Many methods, like beta-blockers, deep inhalational anaesthesia, intravenous lignocaine, calcium channel blockers and direct acting vasodilators, have been tried to blunt these harmful pressor responses associated with laryngoscopy and endotracheal intubation. Intravenous lignocaine is a popular method of blunting this response, because of its ability to depress the myocardium and membrane stabilization effect. Diltiazem, a calcium channel blocker can blunt these responses because of its direct acting vasodilating properties and negative chronotropic effect. In view of it, the present study was undertaken to compare the effects of 1.5 mg/kg lignocaine IV given 3 minutes before laryngoscopy and intubation, Diltiazem 0.2 mg/kg IV given 60 seconds before laryngoscopy and intubation and combination of 0.2 mg/kg of diltiazem IV and 1.5 mg/kg of lignocaine IV given 60 seconds before laryngoscope and intubation on laryngoscopic reactions. It was noted that,both lignocaine and diltiazem attenuated the pressor response to laryngoscopy and endotracheal intubation compared to control group. However, the combination of lignocaine and diltiazem gave better protection against the laryngoscopic reaction than when either of the drugs was given alone.
Authors and Affiliations
Mohan K| Department of Anaesthesia, Department of Pharmacology, Sri Sathya Sai Medical College & Research Institute, Tiruporur, Guduvancherry, Ammapettai, Sembakkam, Tamilnadu, India, Corresponding author email: koyeedoctor@gmail.com, Mohana Rupa L| Department of Pharmacology, Sri Sathya Sai Medical College & Research Institute, Tiruporur, Guduvancherry, Ammapettai, Sembakkam, Tamilnadu, India
Keywords
Related Articles
- EP ID EP11017
- DOI 10.5958/j.2319-5886.2.3.098
- Views 356
- Downloads 21
Use of LDA combined with PLS for classification of lung cancer gene expression data
Reliable and precise classification is essential for successful diagnosis and treatment of cancer. Thus, improvements in cancer classification are increasingly sought. Linear discriminant analysis (LDA) is the most effe...
LUPUS VULGARIS FOLLOWING EAR-PIERCING
In India, two-thirds of cutaneous tuberculosis cases are found to be lupus vulgaris. Lupus vulgaris could be due to primary or secondary infection to Mycobacterium tuberculosis. Innumerable cases of lupus vulgaris, se...
CASE OF CHOLEDOCHAL CYST PRESENTING AS PERFORATION ABDOMEN
Introduction: Choledochal cyst is an uncommon congenital anomaly of Hepoatobiliary system. It is a case of choledocal cyst presenting as perforation and biliary ascites which is rare in infants. Clinical picture: An in...
DHAT SYNDROME AND ITS ASSOCIATION WITH SEXUAL BEHAVIOR AND PYSCHIATRIC COMORBIDITIES IN MALES: A CASE CONTROL STUDY
Background: Dhat syndrome is often taken as culture bound syndrome (CBS) of Indian subcontinent. There are many misconceptions which form base of symptoms and co morbidities. Aim: Dhat syndrome is reported on basis of...
ROLE OF COLOUR DOPPLER SONOGRAPHY IN ADNEXAL MASSES
Objective: To evaluate the role of colour Doppler sonography in differentiating between benign and malignant adnexal masses. Materials & Methods: One hundred women diagnosed with adnexal masses underwent colour Doppler...