ATTENUATION OF CARDIOVASCULAR RESPONSES TO LARYNGOSCOPY AND INTUBATION BY DILTIAZEM AND LIGNOCAINE: A COMPARATIVE STUDY
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2013, Vol 2, Issue 3
Abstract
The study has been designed to investigate the attenuation of cardiovascular responses to laryngoscopy and intubation by diltiazem and lignocaine. Endotracheal intubation is often associated with a hypertension and tachycardia. This response is primarily because of sympatho-adrenal stimulation, associated with laryngoscopy and endotracheal intubation. The rise in the heart rate (HR) and blood pressure increases the myocardial oxygen demand. This increase is tolerated well by normal healthy individuals. However, in patients with Ischemic heart disease (IHD), Hypertensive heart disease and cerebrovascular disease, this sudden rise of heart rate and blood pressure can produce deleterious effects, in the form of myocardial ischemia, pulmonary oedema and cerebral haemorrhage. Many methods, like beta-blockers, deep inhalational anaesthesia, intravenous lignocaine, calcium channel blockers and direct acting vasodilators, have been tried to blunt these harmful pressor responses associated with laryngoscopy and endotracheal intubation. Intravenous lignocaine is a popular method of blunting this response, because of its ability to depress the myocardium and membrane stabilization effect. Diltiazem, a calcium channel blocker can blunt these responses because of its direct acting vasodilating properties and negative chronotropic effect. In view of it, the present study was undertaken to compare the effects of 1.5 mg/kg lignocaine IV given 3 minutes before laryngoscopy and intubation, Diltiazem 0.2 mg/kg IV given 60 seconds before laryngoscopy and intubation and combination of 0.2 mg/kg of diltiazem IV and 1.5 mg/kg of lignocaine IV given 60 seconds before laryngoscope and intubation on laryngoscopic reactions. It was noted that,both lignocaine and diltiazem attenuated the pressor response to laryngoscopy and endotracheal intubation compared to control group. However, the combination of lignocaine and diltiazem gave better protection against the laryngoscopic reaction than when either of the drugs was given alone.
Authors and Affiliations
Mohan K| Department of Anaesthesia, Department of Pharmacology, Sri Sathya Sai Medical College & Research Institute, Tiruporur, Guduvancherry, Ammapettai, Sembakkam, Tamilnadu, India, Corresponding author email: koyeedoctor@gmail.com, Mohana Rupa L| Department of Pharmacology, Sri Sathya Sai Medical College & Research Institute, Tiruporur, Guduvancherry, Ammapettai, Sembakkam, Tamilnadu, India
The Comparison of dental status and oral health related quality of life among children 3-6 years old suffering from Congenital Heart diseases and healthy children
There are a wide range of oral problems in children which interfere with natural function, sense of health, and child's life quality in general. Congenital heart diseases are also considered as one of the most prevalent...
PERSISTENT ARRHYTHMIAS AFTER ELECTROCUTION IN A PATIENT SCHEDULED FOR GRAFT SURGERY
PVC may occur due to numerous etiologies. Manifestations may range from an asymptomatic presentation to ventricular fibrillation and death. The incidence of PVC in healthy population may range from 0.5% in those aged b...
Comparison of self-concept and self-efficacy between non-residential and residential elderly people in nursing homes of Iranian population
Self-concept and self-efficacy are important variables in the field of aging, which less attention has been paid to them. This study was conducted to determine and compare the non-residential and residential elderly peo...
Co-occurrence of Gardnerellavaginalis and Candida sp. in women with and without vulvovaginitis
Aims: To detect the co-occurrence of Gardnerellavaginalis and Candida sp.in women with and without vaginal symptoms. Methods: A cross-sectional study was performed in women seeking treatment in a Brazilian city from Ma...
Effect of number of cigarettes smoked per day on red blood cell, lecocyte and platelet count in adult Indian male smokers – A case control study
The effects of cigarette smoking are fatal. Present study was done to compare cell counts of blood in males smoking different number of cigarettes per day and non smokers of Hyderabad city. 150 consenting subjects of wh...