Attenuation of depression by Bauhinia purpurea linn. leaves ethanolic extract in swiss albino mice
Journal Title: IP International Journal of Comprehensive and Advanced Pharmacology - Year 2017, Vol 2, Issue 3
Abstract
Introduction: Depression is a characterised by low mood and lack of activity that can implicit on person's thoughts, behaviour, feelings, and sense of well-being. Objectives: To evaluate antidepressant activity of Ethanolic extract of Bauhinia Purpurea in Swiss Albino mice. Materials and Method: Sixty Swiss Albino mice of either sex weighing 20-25gm were divided into five groups, Group I received vehicle (1% Gum acacia suspension - 3ml/kg P.O), Group II received standard drug Imipramine (10mg/kg orally 1 hour before the experiment). Group III, IV, V received the test drug in the dose of 100 mg/kg, 250mg/kg, and 500mg/kg respectively. Experiment was done by Forced swim test (FST) and Tail suspension test (TST) and duration of mobility and immobility were considered during the last 4 minutes in the 6 minutes test. Statistical analysis: Dunnett’s test. P < 0.05 was considered as significant. Results: Administration of ethanolic extract of Bauhinia Purpurea at the dose of 500mg/kg produced significant decrease in immobility time in both the models with a P value of < 0.05. Conclusion: Administration of ethanolic extract of Bauhinia Purpurea at the dose of 500mg/kg has produced statistically significant decrease in immobility time in both the models.
Authors and Affiliations
Prathvi Shetty, Manohar V. R. , Sara Kurien, Mohandas Rai
Keywords
Related Articles
- EP ID EP319477
- DOI 10.18231/2456-9542.2017.0003
- Views 65
- Downloads 0
Annona squamosa: Seetaphal: A review
Alterative medication and natural remedies have been used from ancient time for the treatment and wellbeing of human. Medicinal plants are considered to be effective and for most important for the above purposes. The Mot...
Retrospective pharmacoeconomic evaluation of two types of cataract surgeries in a private hospital: cost effectiveness analysis
Objective: Cataract surgery is performed by two methods; small incision cataract surgery (SICS) and topical phacoemulsification (TPE) with intraocular lens (IOL) implantation. SICS is a widely used method but technologic...
Efficacy of tacrolimus in steroid dependent and steroid resistant childhood nephrotic syndrome - A retrospective study
Introduction Nephrotic syndrome is a common renal disease in children Majority of the children usually responds to steroids without any long term effects on kidney function However about 1020 of children are usually ster...
Alternative therapies of neuropsychiatric disorders
Therapies are termed as Complementary when used in addition to conventional treatments and as alternative when used instead of conventional treatment. These therapies are less researched than conventional therapies & som...
A retrospective study on prescription pattern of drugs used in myocardial infarction in a South Indian Tertiary Care Hospital
Introduction Angina pectoris the primary symptom of ischemic heart disease is caused by transient episodes of myocardial ischemia that are due to imbalance in the myocardial oxygen supplydemand relationship Various drugs...