Attenuation of Haemodynamic Stress Response to Laryngoscopy and Intubation with two Doses of Esmolol Hydrochloride
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 5
Abstract
Direct laryngoscopy and endotracheal intubation is associated with reflex cardiovascular responses mediated by the sympathetic nervous system. Various drugs have been used to attenuate these haemodynamic responses. Esmolol, an ultra short acting β blocker with rapid onset of action is suitable for attenuation of hemodynamic response to laryngoscopy and intubation. A prospective observational study was done with 3 groups of 30 patients each presenting for elective surgery. For attenuation of stress response to intubation, Group A received no drug, Group B received intravenous esmolol 1mg/kg, 1 minute before induction and Group C received intravenous esmolol 2mg/kg 1minute before induction. Heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure and rate pressure product were recorded before induction,1minute, 3minute, 5minute, 7minute and 10 minute intervals after induction. It was found that there is a significant hemodynamic response to laryngoscopy and intubation in those who did not receive any drug for hemodynamic response attenuation. Esmolol in a bolus dose of 1mg/kg(B) and 2mg/kg(C) given 1minute before induction effectively attenuated the hemodynamic response to laryngoscopy and intubation. Group C was often associated with systolic blood pressure lesser than the pre-induction values. Esmolol in a bolus dose of 1mg/kg given 1minute before induction is therefore the recommended dose for attenuation of hemodynamic response to laryngoscopy and intubation.
Authors and Affiliations
Susan T. Cheeran
Keywords
Related Articles
- EP ID EP285436
- DOI -
- Views 75
- Downloads 0
Utility of serum ADA estimation in the diagnosis of extrapulmonary tuberculosis
Background: Adenosine deaminase (ADA) has largely been studied in body fluids for the diagnosis of extra pulmonary tuberculosis (EPTB). Serum ADA has been used as non-invasive assay for Pulmonary TB. The aim of the prese...
Effect of Exercise Program on Acromiohumeral Distance in Subacromial Impingement Syndrome
Among painful shoulder conditions, Shoulder Subacromial impingement syndrome is the most common cause, Acromiohumeral distance changes commonly reported in shoulder impingements. Objective: of this study was to evaluate...
A Cross-sectional Study of Road Traffic Accidents at a Tertiary Care Hospital in Jaipur City, Rajasthan
Introduction: Injuries related to road traffic accidents (RTA) contribute to significant increase of the number of trauma admissions at tertiary care centre, taking out a significant number of lives and resources. We nee...
Noninvasive Markers for the Assessment of Liver Fibrosis and Cirrhosis in Egyptian Patients with Chronic Hepatitis C and Schistosomiasis Coinfection
To assess the role of noninvasive biomarkers in patients with chronic hepatitis C virus (HCV) and schistosomiasis coinfection and to correlate them with hepatic fibrosis and activity. This study was carried out on one hu...
Clinical Profile and Outcome of Caesarean Scar Pregnancy in a Tertiary Care Center - A One Year Study
Caesarean scar ectopic is a rare but significant variant of ectopic pregnancy where the implantation is in the cesarean scar. Objective: To study the clinical profile and outcome of cesarean scar pregnancy during the yea...