Attenuation of sympathomimetic response to laryngoscopy and intubation: Comparative study of esmolol and labetalol treatment
Journal Title: MedPulse -International Medical Journal - Year 2017, Vol 4, Issue 5
Abstract
Background: The sequence of induction of anesthesia, laryngoscopy and tracheal intubation are associated with marked hemodynamic changes and autonomic reflex activity which may be a cause of concern in many high risk patients. It is a sympathetic reflex associated with increase plasma norepinephrine concentration and is not prevented by routine premedication. These changes may lead to a number of complication which include myocardial ischemia/infarction, cardiac failure, intracranial haemorrhage and increase in intracranial pressure. In the present study, the efficacy of intravenous Esmolol and Labetolol for attenuating cardiovascular response following larngoscopy and intubation have been compared and evaluated in normotensive surgical patients. Aim and objective: 1.To study rise in heart rate while laryngoscopy and intubation in Esmolol treated group compared to Labetalol treated group. 2. To study rise in SBP, DBP & MAP while laryngoscopy and intubation in Esmolol treated group compared to Labetalol treated group. Material and methods: Sixty patients of American Society of Anaesthesiologists (ASA) grade I and II undergoing elective surgical procedure, requiring general anaesthesia were divided into 2 groups, Group A patients (30) were given ESMOLOL 1 mg/kg n & Group B (30 patients) were given LABETOLOL 0.25mg/kg. Results & Discussion: There is significant difference among mean pulse rate changes from baseline among two groups up to 15 min after study drug. There was significant difference in mean changes in mean arterial pressure and systolic blood pressure from immediately after intubation up to 15 min post intubation. In diastolic blood pressure there was no significant difference in mean changes between two groups at all points of study, except 3 min after intubation which is an isolated finding. There was no significant difference in spo2 between two groups at all points of study.
Authors and Affiliations
Kinjal J Anand, Preeti D Jadeja
Keywords
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