Abstract

Dear Editor, Human primary immunodeficiency disease (PID) is a condition where mutations in single immune system genes predispose individuals to certain infectious agents. The human herpesviruses are a challenge of immune competence, since most of these agents are widespread in the population; they are often acquired silently or with mild symptoms in childhood and then carried for life as asymptomatic latent infections. PID patients are therefore likely to be exposed to these viruses relatively early in life and will have to deal with them both as a primary infection and as a persistent condition.1 For individuals who are immunocompromised, due to a genetic immunodeficiency or immunosuppressive drug therapy, viral infections may result in severe complications and even life-threatening disease.2

Authors and Affiliations