Autoantibodies and Wrist Synovitis in Early Rheumatoid Arthritis, UltraSonographic Study
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 1
Abstract
Several autoantibodies has been linked to rheumatoid arthritis, diagnosis but its relation to joint synovitis needs to be evaluated. Aim of the work: To investigate the relation between rheumatoid factor, anti-cyclic citrullinated peptide, and anti-mutated citrullinated vimentin and ultrasound detected wrist synovitis in female patients with early rheumatoid arthritis. Patients and Methods: 80 female patients with early rheumatoid arthritis presenting at outpatient rheumatology clinics of AL-AZHAR University Hospitals Egypt through 2015-2016, were assessed for DAS28, rheumatoid factor, anti-cyclic citrullinated protiens (Anti CCP), anti-mutated citullinated vimentin (Anti MCV), and ultrasound quantification of wrist synovitis using gray scale and power Doppler. Results: A significant positive correlation has been found between the Anti MCV and DAS28, where p> 0.05. A highly significant correlation found between Anti MCV, synovitis in gray scale and power Doppler were p> 0.01. Correlation study of Anti CCP, shows a highly significant correlation found between Anti CCP, DAS28, and synovitis in gray scale and power Doppler were p> 0.01. While rheumatoid factor fails to have any significant correlation with ultrasound parameters. Conclusion: Anti CCP, and anti MCV are significantly correlated with wrist synovitis in female patients with early rheumatoid arthritis with superior correlation to anti CCP with the clinical activity
Authors and Affiliations
Ahmed Fathy Abogamal
Keywords
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