Autoantibodies spectrum in HCV and HBV infected patients
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2013, Vol 7, Issue 2
Abstract
Hepatitis B and C viruses have the potential for generating autoimmune processes with dysregulation of the cytokines, Th1 chemokines and molecular or epitope mimicry between self-antigens and viral proteins. These phenomena include the production of autoantibodies, but their clinical significance is still unknown. The aim of this study was to determine the presence of autoantibodies in HCV compared to HBV infected patients, and to find the association of their presence with the age, sex and microscopical changes in the liver. The incidence of autoantibodies presence parallel to the liver biopsy was assessed in 363 consecutive patients with hepatitis C, and 71 patients with hepatitis B. It was found that 66 (18%) HCV and 8 (11%) HBV infected patients had positive results. Pathomorphological changes typical for autoimmune hepatitis were not found in this group of patients with viral infection. The HCV infected patients with autoantibodies were significantly older than patients without autoantibodies. This correlation could be connected with the orsening of the self-mechanisms protecting against autoimmune reactions and the longer duration specially of HCV infection. No such similar correlation was observed in the group of HBV infected patients.
Authors and Affiliations
Joanna Cielecka-Kuszyk, Tomasz Chmielewski, Milena Dunal-Szczepaniak, Joanna Siennicka
Keywords
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