Autoantibodies spectrum in HCV and HBV infected patients
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2013, Vol 7, Issue 2
Abstract
Hepatitis B and C viruses have the potential for generating autoimmune processes with dysregulation of the cytokines, Th1 chemokines and molecular or epitope mimicry between self-antigens and viral proteins. These phenomena include the production of autoantibodies, but their clinical significance is still unknown. The aim of this study was to determine the presence of autoantibodies in HCV compared to HBV infected patients, and to find the association of their presence with the age, sex and microscopical changes in the liver. The incidence of autoantibodies presence parallel to the liver biopsy was assessed in 363 consecutive patients with hepatitis C, and 71 patients with hepatitis B. It was found that 66 (18%) HCV and 8 (11%) HBV infected patients had positive results. Pathomorphological changes typical for autoimmune hepatitis were not found in this group of patients with viral infection. The HCV infected patients with autoantibodies were significantly older than patients without autoantibodies. This correlation could be connected with the orsening of the self-mechanisms protecting against autoimmune reactions and the longer duration specially of HCV infection. No such similar correlation was observed in the group of HBV infected patients.
Authors and Affiliations
Joanna Cielecka-Kuszyk, Tomasz Chmielewski, Milena Dunal-Szczepaniak, Joanna Siennicka
Keywords
Related Articles
- EP ID EP58794
- DOI -
- Views 162
- Downloads 0
Impact of heavy metals on the female reproductive system
Introduction. It has been recognized that environmental pollution can affect the quality of health of the human population. Heavy metals are among the group of highly emitted contaminants and their adverse effect of livi...
Differences in health – a global problem and its various aspects
Annals of Agricultural and Environmental Medicine (AAEM) is the journal in the columns of which for many years the scope of problems has been discussed concerning the effect of environmental hazards on the human body. It...
Socio-demographical and psychosocial determinants of anxiety symptoms in a population of pregnant women in the regions of central and eastern Poland
Introduction and objective. Until recently, depression and anxiety during pregnancy were a neglected medical problem. The purpose of this study was to determine the prevalence of symptoms of anxiety and depression during...
Effect of repetitive mowing on common ragweed (Ambrosia artemisiifolia L.) pollen and seed production.
Ambrosia artemisiifolia L (common ragweed) is a familiar roadside weed in southern Quebec (Canada) that produces large amounts of airborne pollen responsible for multiple rhino-conjunctivitis (hay fever) cases. As roadsi...
Serological survey in persons occupationally exposed to tick-borne pathogens in cases of co-infections with Borrelia burgdorferi, Anaplasma phagocytophilum, Bartonella spp. and Babesia microti
Sera of 39 farmers, 119 foresters and 32 blood donors were investigated for the presence of antibodies against [i]B. burgdorferi[/i], [i]A. phagocytophilum[/i], [i]B. microti[/i] and [i]Bartonella[/i] spp. Semi-quantitat...