Autoantibody Positivity in Children with Chronic Diarrhea
Journal Title: The Journal of Pediatric Research - Year 2020, Vol 7, Issue 3
Abstract
Aim: We aimed to determine the frequency of autoantibody antinuclear (ANA), peripheral anti-neutrophil cytoplasmic antibody (p-ANCA), anti-Saccharomyces cerevisiae antibody (ASCA), anti-pancreatic exocrine gland antibody (PAb), goblet cell antibody (GAb) positivities in children with the complaint of chronic diarrhea and inflammatory bowel disease (IBD). We also purposed to explore the role of these autoantibodies in the differential diagnosis of IBD. Materials and Methods: In our study, serum samples of 51 patients with the complaint of chronic diarrhea and 35 healthy controls were analyzed. Clinical and laboratory data at the time of serum sampling were collected and a differential diagnosis was made as the results of performed tests were recorded. For all patients, ANA, p-ANCA, ASCA, GAb, PAb positivities were evaluated by indirect immunofluorescence. The chronic diarrhea group was divided into two groups, namely, the IBD group and non-IBD group. Results: In the chronic diarrhea group, 11 (21.6%) patients had ANA, 3 (5.9%) had p-ANCA, 1 (2%) had PAb, 1 (2%) had Gab and 1 (2%) had ASCA positivity. From the 35 cases of the control group, 8 (22.9%) had ANA, 7 (20%) had ASCA positivity. In the control group, ASCA was found to be high (p=0.007). Six cases were diagnosed as IBD; 1 (16.7%) had ANA, 1 (16.7%) had p-ANCA, 1 (2%) had Gab and 1 (2%) had ASCA positivity. ASCA and GAb positivities were significantly more frequent in the IBD group (p=0.006, p=0.006, respectively). Conclusion: ASCA was determined to be significantly higher in the control group. High positivity in the control group showed that the percentage of nonspecific positivity may be high for this test. ASCA and GAb of those patients with a diagnosis of IBD were found significantly higher. The serologic tests which depend on p-ANCA, ASCA, PAb, GAb can be supportive of diagnoses and differential diagnoses of IBD. Autoantibodies in IBD may be used as a supportive diagnostic tool in selected cases, rather than as the diagnosis of IBD as routine practice.
Authors and Affiliations
Hale Tuhan, Aslı Aslan, Çiğdem Ecevit, Elif Azarsız, Neslihan Karaca, Funda Çetin, Necil Kütükçüler, Güzide Aksu
Keywords
Related Articles
- EP ID EP685492
- DOI 10.4274/jpr.galenos.2020.13008
- Views 148
- Downloads 0
How Parents of Children with Cancer Seek Information Through Online Communities: A Netnography Study
Canan Sümeyra Gün, Selmin Şenol
A Novel Mutation in Fanconi Bickel Syndrome Diagnosed in the Neonatal Period
Fanconi Bickel Syndrome (FBS), also known as glycogen storage disease Type XI, is a rare autosomal recessive disorder. This syndrome has many different identified mutations and it is rarely diagnosed during the neonatal...
Psychometric Properties of the Turkish Version of the ‘Nine to Eleven-Year-Olds’ Attitudes Towards Breakfast Questionnaire
Aim: This study has been carried out to evaluate the validity and reliability of the Turkish version of the ‘9 to 11-Year-Olds’ Attitudes towards Breakfast Questionnaire. Materials and Methods: This study was conducted...
Early Neonatal Outcomes in Premature Rupture of Membranes Beyond Twenty-eight Weeks of Gestation in a Tertiary Care Hospital of Coastal Karnataka
Aim: Premature rupture of membranes (PROM) is a significant risk factor for various adverse neonatal outcomes such as prematurity, respiratory distress, birth asphyxia and early onset neonatal sepsis. Due to the public h...
Evaluation of the Relationship between Mucosal Diseases and Faecal Calprotectin Levels in Children who Underwent Upper Gastrointestinal System Endoscopy
Aim: In this study, the correlation of faecal calprotectin (FC) levels with endoscopic and histopathological findings was evaluated in children who underwent upper gastrointestinal system (UGIS) endoscopy. Materials and...