AUTOIMMUNE POLYENDOCRINE SYNDROME TYPE 1 (APS-1): MORE THAN CHRONIC MUCOCUTANEOUS (CMC) DYSTROPHY, HYPOPARATHYROIDISM (HP) AND ADRENAL INSUFFICIENCY (AAD)
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH - Year 2015, Vol 7, Issue 7
Abstract
We report an eight year-old Saudi girl who was diagnosed to have chronic-mucocutaneous-candidiasis (CMC), and hypoparathyroidism (HP) i.e. autoimmune polyendocrine syndrome type 1 (APS-1). She was shortly manifested symptoms and signs of autoimmune adrenal insufficiency (AAD). During the course of follow-up, and within a short period of time she developed hypothyroidism with positive anti-thyroid antibodies, type 1 diabetes mellitus with elevated glutamic acid decarboxylase 65 (GAD 65), celiac disease, small bowel biopsy proved, pernicious anemia, kerato-conjunctivitis. She died at the age of 14, with acute hepatic failure, due to an autoimmune hepatitis, and over-wheeling sepsis. The spectrum of APS-1 was highlighted.
Authors and Affiliations
Nasir A. M. Al Jurayyan, 1Amer O. Al Ali, 1Osamah A. Al Ayed, 1Sharifa D. A. Al Issa . , Abdullah N. Al Jurayyan
Keywords
Related Articles
- EP ID EP405553
- DOI -
- Views 118
- Downloads 0
Survival of Patients Using Antiretroviral Therapy by Pass Stigma, South Ethiopia
Human Immunodeficiency Virus| Acquired Immune Deficiency Syndrome (HIV|AIDS) has become the common deadly chronic disease. Provision of antiretroviral drugs is believed in reducing the effect of stigma and social discrim...
Ebola and its associated social determinants of health – a public health perspective
Background: The Ebola outbreak is a deadly disease of the African population which has captured the interest of the global community. The pace and fatality rate of the disease requires a ‘global intervention’, with publi...
Antibiotics aren’t we over prescribing? a cross sectional study
Introduction: - It has been reported that the over-prescription of antibiotics in children is leading to increased fatal diarrheal cases and a drastic change in the sensitiveness of gut flora. The American Academy of Ped...
Hypertension related aortic regurgitation [HT –related AR], its prevalence and prognostic significance
Aortic Regurgitation [AR] is diastolic flow of blood from aorta to left ventricle. AR could be acute or more commonly chronic. chronic AR could congenital or acquired .it could be due to valve leaflet pathology,...
Height prediction by measuring ulnar length in females
Context: Stature estimation is frequently required by the Forensic Science experts which more often done on the skeletal remains. Since 1950`s the long bones in the human body for eg Humerus, ulna, Femur and Tibia are us...