Autologous leukocyte-poor platelet-rich plasma injection in the treatment of knee osteoarthritis: short-term clinical effect analysis
Journal Title: Chinese Journal of Blood Transfusion - Year 2024, Vol 37, Issue 10
Abstract
Objective To investigate short-term clinical efficacy of autologous leukocyte-poor platelet-rich plasma(LP-PRP) treatment of knee osteoarthritis(KOA). Methods 85 cases of patients with Keligren Lawrence grade Ⅰ-Ⅲ knee osteoarthritis in Peking University First Hospital Taiyuan Hospital (Taiyuan Central Hospital) from 2022 to 2023 were collected for autologous LP-PRP collection and quality assessment using a blood component separator, and all patients were treated with autologous LP-PRP. The degree and function of knee pain were assessed by visual analog scale(VAS) and knee arthritis index scale(WOMAC) at 1, 3 and 6 months after injection. Knee MRI was performed after 6 months of treatment, and the MRI imaging changes before and after treatment were compared. Different influencing factors in the treatment results were grouped and analyzed, mainly including platelet concentration in LP-PRP and K-L grading of knee joint. According to the platelet concentration in LP-PRP, it was divided into three grades, which are low concentration[(<800)×109/L], medium concentration[(800-1 000)×109/L], and high concentration[(>1 000)×109/L]; According to the K-L grade of the knee joint, the severity of knee osteoarthritis was divided into three grades: Ⅰ、Ⅱ、Ⅲ. Results The VAS and WOMAC scores at 1, 3 and 6 months after LP-PRP treatment were significantly lower than those before treatment, and the difference was statistically significant (P<0.05). There was a statistically significant difference in the therapeutic effect of different levels of platelet concentration, and when the platelet concentration was more than 1 000×109/L, the significant effect was the most obvious(P<0.05). The therapeutic effect of different levels of platelet concentration was statistically significant(P<0.05). MRI showed that the articular cartilage signal was significantly improved after treatment. Conclusion Autologous LP-PRP injection into knee cavity for the treatment of KOA has a good short-term clinical effect in relieving knee pain.
Authors and Affiliations
Lei YANG, Doudou JING, Mingxi LIU, Zhenye GUO, Binai YANG, Shuzhong LIN, Demei ZHANG, Fengyan GUO, Jin LIU
Keywords
Related Articles
- EP ID EP749833
- DOI 10.13303/j.cjbt.issn.1004-549x.2024.10.004
- Views 27
- Downloads 0
Analysis of donation related vasovagal reactions in Hefei
Objective To explore the influencing factors and characteristics of blood donation-related vasovagal reactions in whole blood donation in Hefei city, and to put forward specific prevention measures. Methods Whole blood d...
Changes in perioperative blood group antibody of 33 type-A/B recipients in ABO-incompatible kidney transplantation
Objective To statistically analyze the perioperative results of patients with ABO-incompatible kidney transplantation (ABOi-KT), in order to explore the changes in blood group antibody of type-A/B recipients. Methods A t...
Correlation between unexpected antibody types and transfusion efficacy in patients with autoimmune hemolytic anemia (AIHA)
Objective To analyze the antibody types of autoimmune hemolytic anemia(AIHA) patients in Panyu district, Guangzhou and track the therapeutic effect of blood transfusion, so as to provide reference for clinical transfusio...
Comparison of centrifugal-membrane hybrid plasmapheresis and centrifugation therapeutic plasma exchange in hyperlipidemia
[Objective] To establish a new centrifugal-membrane hybrid plasmapheresis (CMHP) model, and observe its clinical efficacy, safety and advantages in the treatment of hyperlipidemia by comparing with centrifugation therape...
Molecular genetic analysis and predigree of a new FUT1 allele of para-Bombay blood group: a case report
Objective To study the serological and molecular mechanism of a case of para-Bombay blood group caused by 236delG mutation of FUT1 gene and investigate the pedigree. Methods The ABO, H and Lewis antigens of the proband a...